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Relevance of Serum Leptin and Leptin-Receptor Concentrations in Critically Ill Patients The adipocyte-derived cytokine leptin was implicated to link inflammation and metabolic alterations. We investigated the potential role of leptin components in critically ill patients, because systemic inflammation, insulin resistance, and hyperglycemia are common features of critical illness. Upon admission to Medical Intensive Care Unit (ICU), free leptin and soluble leptin-receptor serum concentrations were determined in 137 critically ill patients (95 with sepsis, 42 without sepsis) and 26 healthy controls. Serum leptin or leptin-receptor did not differ between patients or controls and were independent of sepsis. However, serum leptin was closely associated with obesity and diabetes and clearly correlated with markers of metabolism and liver function. Leptin-receptor was an unfavourabl...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Chemical for keeping human pluripotent stem cells alive identified Researchers have found that a chemically synthesized compound, blebbistatin, can help prevent cell death in human pluripotent stem cells. These cells are of interest to stem cell scientists working on finding therapies for spinal cord injuries, Parkinson's disease, burns, heart disease, diabetes, arthritis, and other ailments. Another advantage of using blebbistatin, say the researchers, is that no human- or animal-derived materials is needed for coating the culture surfaces. (Source: ScienceDaily Headlines) A new role for insulin in cell survival, cell metabolism and stress response Researchers have discovered a novel way in which insulin affects cell metabolism and cell survival. Surprisingly the insulin signaling pathway, which is involved in aging, diabetes and stress response, is active at a deeper level of cell activity than scientists expected. (Source: ScienceDaily Headlines) Clinical Insights in Type 2 Diabetes e-Newsletter: An e-Newsletter containing reviews of current literature and the latest information on the management of type 2 diabetes and cardiovascular disease (Source: Current CME-Certified Activities from Thomson Professional Postgraduate Services) CME On-Demand On-Demand: CME Video Vignettes, CME Interactive Case Studies, and more (Source: Current CME-Certified Activities from Thomson Professional Postgraduate Services) P2.29 Progressions of (CTG) n expansions, muscular disability rating scale (MDRS), and abnormal glucose metabolism are age dependent in myotonic dystrophy type 1 (DM 1) Conclusion: Both muscular involvement and AGM in DM1 might be progressed with age-dependent (CTG) n expansion. (Source: Neuromuscular Disorders)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> P2.30 Oral fat loading study ? does specific hyperlipemia exist in myotonic dystrophy type 1? Conclusion: Only FFA showed significant difference in the loading test between MD1 and controls. The lower level of FFA in MD1 could reflect effects of insulin itself. Our results suggested that MD1 had no specific postprandial hyperlipemia. Abnormality of lipid metabolism in MD1 should be clinically treated as secondary hyperlipemia. (Source: Neuromuscular Disorders) The real war on drugs Nature Medicine 16, 948 (2010). doi:10.1038/nm0910-948 Author: Cassandra Willyard The murder of ten aid workers, including an optometrist and a surgeon, in Afghanistan last month refocused the world's attention on the difficulties of providing health care in conflict zones. Beyond the dangers of delivering acute care such as surgery, dispensing medicines for chronic illnesses ranging from HIV to diabetes remains a challenge in areas affected by war. Cassandra Willyard looks at the lessons relief agencies have learned in recent years providing care amidst increasingly complex conflicts. (Source: Nature Medicine) Risk factors for albuminuria, renal impairment in Type 2 diabetes revealed Swedish researchers have found that older age, high systolic blood pressure, and high triglycerides increase the risk for albuminuria and renal impairment in patients with Type 2 diabetes. (Source: MedWire News - Diabetes) Methylprednisolone/prednisolone: Avascular necrosis of femoral heads and post-transplant diabetes mellitus: case report (Source: Reactions) Increased tissue leptin hormone level and mast cell count in skin tags: A possible role of adipoimmune in the growth of benign skin growths Conclusion: This is the first report to demonstrate that tissue leptin may play a role in the pathogenesis of ST. The significant increase in the levels of leptin and mast cell count in ST may indicate a possible role of adipoimmune in the benign skin growths. (Source: Indian Journal of Dermatology, Venereology and Leprology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Cognition problems linked to physical ills EDMONTON, Alberta, Sept. 7 (UPI) -- People with diabetes and high blood pressure who walk slowly or lose balance or say they're in bad health may have cognition issues, Canadian researchers say. Alberta - Canada - Edmonton - Hypertension - Health (Source: Health News - UPI.com) Short Sleepers at Higher Risk of Diabetes and Heart Disease People who sleep less than six hours a night may be three times more likely to develop a condition which leads to diabetes and heart disease, according to researchers at the University of Warwick. (Source: Disabled World) Incentivising GPs cuts heart disease deaths and admissions QOF monies iron out inequalities in access to healthcare as well as health outcomes, study showsRelated items from OnMedicaLicensing process for top selling diabetes drug under fireAntihypertensive drugs vary in heart attack riskRisk/benefit balance of alteplase shifts quicklyCare homes drug error rate raises concernsFake medicine warning hits cinemas (Source: OnMedica Latest News) Animal-Based Low-Carbohydrate Diet Linked to Higher All-Cause Mortality Rates An animal-based low-carbohydrate diet was associated with higher all-cause mortality, but a vegetable-based low-carbohydrate diet was linked with lower all-cause and cardiovascular disease mortality. Medscape Medical News (Source: Medscape Today Headlines) US Patients Going Straight To Emergency Department, Bypassing Personal Physicians Every wondered why emergency departments in the USA are so crowded? The answer seems to be in people's changing behaviors over the last few years. Today, only 45% of the 354 million yearly visits for acute care in the USA are made to the patient's personal doctor, while an enormous number are going straight to emergency departments, seeing specialists, or turning up at outpatient care departments as their first point of call for treatment for new health problems, episodes, or a flare-up of a chronic health condition, such as diabetes or asthma... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Short sleepers at higher risk of type 2 diabetes and heart disease, study finds People who sleep less than six hours a night may be three times more likely to develop a condition which leads to diabetes and heart disease, according to researchers. (Source: ScienceDaily Headlines) A New Role for Insulin in Cell Survival, Cell Metabolism and Stress Response September 7, 2010 (EurekAlert) - Researchers at the Buck Institute for Age Research have discovered a novel way in which insulin affects cell metabolism and cell survival. Surprisingly the insulin signaling pathway, which is involved in aging, diabetes and stress response, is active at a deeper level of cell activity than scientists expected. The study appears in the September 8th issue of Cell Metabolism. read more (Source: Diabetes News from dLife.com) Guidelines for Glycemic Control and Individualized Targets [Letters] (Source: JAMA) Guidelines for Glycemic Control and Individualized Targets--Reply [Letters] (Source: JAMA) Reducing the Risk of CVD in Patients with Periodontitis The association between periodontitis and other chronic diseases, such as cardiovascular disease and type 2 diabetes, could be related to systemic inflammation initiated by a local inflammatory challenge. Nature Reviews Cardiology (Source: Medscape Diabetes Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> NIH Study Shows How Insulin Stimulates Fat Cells to Take in Glucose Source: National Institute of Child Health and Human Development, National Institute of Diabetes and Digestive and Kidney Diseases - Related MedlinePlus Page: Diabetes (Source: MedlinePlus Health News) It's Not Your Fault - Blame Biology! I turn on the TV and find a commercial informing me that I should Blame Biology rather than french fries for an outbreak of acne. It is true that biologic factors involved in acne include excess sebum production caused by increased hormones, outlet obstruction of sebaceous follicles and inflammation. Further, research has shown that greasy foods and chocolates won't worsen acne. However, excessive manipulation and rubbing, hair gels, medications, stress and certain foods such as refined sugars and starches will increase oil production and probably the pimple population. In other words, you do have some control over your complexion.This Blame Biology message is not new, nor is it limited to dermatology. We are always looking for something or someone to blame; allowing us to shift resp... Natural killer cells in NOD.NK1.1 mice acquire cytolytic function during viral infection and provide protection against cytomegalovirus [Immunology] Resting natural killer (NK) cells in nonobese diabetic (NOD) mice have impaired immune functions compared with NK cells from other... (Source: Proceedings of the National Academy of Sciences) Heart risk from working late? Conclusion These findings suggest that long working hours may have the greatest effect on mortality risk in men who are physically unfit. There are some points to note: It is possible that the results have been influenced by factors other than the hours men worked and their fitness levels. Although the researchers took into account some factors which could affect results, these or other unknown or unmeasured factors could still be having an effect. For example, while the researchers made adjustments to account for the influence of smoking, smoking was recorded as current, previous or never, rather than by the number of cigarettes smoked. Smoking rates were also unusually high at 65-70% in some analysis groups. Physical fitness and working hours were only assessed at the start of the... Bariatric Operations Reduce Odds of Gestational Diabetes, Cesarean Section September 7, 2010 (EurekAlert) - Obese women who have bariatric surgical procedures before pregnancy were three times less likely to develop gestational diabetes (GDM) than women who have bariatric operations after delivery, according to new research findings published in the August issue of the Journal of the American College of Surgeons. The retrospective study also found that delivery after bariatric procedures was associated with reduced odds of cesarean section?an outcome associated with GDM. read more (Source: Diabetes News from dLife.com)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Short Sleepers At Higher Risk of Type 2 Diabetes and Heart Disease September 7, 2010 (EurekAlert) - People who sleep less than six hours a night may be three times more likely to develop a condition which leads to diabetes and heart disease, according to researchers at the University of Warwick. A study by a team of researchers from Warwick Medical School and the State University of New York at Buffalo has found short sleep duration is associated with an elevated risk of a pre-diabetic state, known as incident-impaired fasting glycaemia (IFG). read more (Source: Diabetes News from dLife.com) Unrelated Kidney Donor Study Shows Age and Obesity Increase Complications September 7, 2010 (EurekAlert) - Patients who have received a new kidney are significantly more likely to develop transplant renal artery stenosis (TRAS) if they are obese or over 50, according to research published in the September issue of the Journal of Renal Care. read more (Source: Diabetes News from dLife.com) CC Grand Rounds: (1) Diabetes Risk in the Workplace: NHLBI's "Keep the Beat" Worksite Wellness Program (2) Heart Disease: Risk Factors and Race Presented by: Richard O. Cannon, III, MD, and Anne E. Sumner, MDCategory: Clinical Center Grand RoundsAired date: 09/01/2010 (Source: Videocast - All Events) UK Drug Regulators Want Avandia Pulled From Market From Canadian Press DataFile (September 6, 2010) LONDON -- GlaxoSmithKline?s controversial diabetes pill Avandia should be pulled from the U.K. market because of concerns that the drug can increase the risk of heart attacks, British... (Source: Drugs.com - Pharma News) What Causes Peripheral Neuropathy? Discussion Peripheral neuropathy is simply a disease of the peripheral nerves. They can be acute (30%) or chronic (about 67%). About 70% of chronic neuropathy in children is hereditary, 20% is indeterminant and 10% is acquired. Peripheral neuropathies are often present with predominantly distal involvement that is bilateral and symmetric. Sensory symptoms can include numbness, dysesthesia or ataxia. Motor symptoms often include weakness. The autonomic nervous system can also be affected with arrhythmias, hypotension, bowel or bladder problems or abnormal sweating. Learning Point The differential diagnosis of peripheral neuropathy includes: Neurologic Abetaliporteinemia Charcot-Marie Tooth Disease Chronic Inflammatory Demyelinating Polyneuropathy Dejerine-Sottas Giant Axonal Neuropathy Gu...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Blood Pressure Control in Diabetes: How Low Should We Go? Could tight blood pressure control in patients with type 2 diabetes and coronary artery disease do more harm than good? Medscape Diabetes & Endocrinology (Source: Medscape Today Headlines) Compounds in Nonstick Cookware May Be Associated with Elevated Cholesterol in Children and Teens September 6, 2010 (EurekAlert) - Children and teens with higher blood levels of chemicals used in the production of non-stick cookware and waterproof fabrics appear more likely to have elevated total and LDL cholesterol levels, according to a report in the September issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals. read more (Source: Diabetes News from dLife.com) Carbohydrate Claims Can Mislead Consumers September 7, 2010 (EurekAlert) - ood manufacturers advertise a variety of foods on grocery store shelves by using nutrient claims on the front of packaging. A study in the September/October issue of the Journal of Nutrition Education and Behavior evaluates how consumers are interpreting certain carbohydrate-related content claims and the effects of claims on consumer perceptions of food products. read more (Source: Diabetes News from dLife.com) Kenya: Diabetes Spread Blamed On Inactive Lifestyles Medical experts have warned about the prevalence of diabetes in Africa, attributing it to a shift to dormant lifestyles. (Source: AllAfrica News: Health and Medicine) GI Dynamics Announces New Data Showing Significant Weight Loss, Cardiovascular and Metabolic Improvements Following 12 Months of EndoBarrier Treatment Obese Patients Achieved Mean Weight Loss of 20%; Data Presented at IFSO 2010 World Congress LEXINGTON, Mass. & LOS ANGELES--(Healthcare Sales & Marketing Network)--GI Dynamics, a leader in non-surgical, endoscopic treatments for type 2 diabetes and obes... Devices, GastroenterologyGI Dynamics, EndoBarrier, Gastrointestinal Liner (Source: HSMN NewsFeed)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Long-term weight loss may be harmful to health HONG KONG (Reuters) - Long-term weight loss may release into the blood industrial pollutants linked to illnesses like diabetes, hypertension and rheumatoid arthritis, researchers said on Tuesday. (Source: Reuters: Health) Sciatic Nerve of Diabetic Rat Treated With Epoetin Delta: Effects on C-Fibers and Blood Vessels Including Pericytes In diabetes mellitus (DM) reduced motor and sensory properties of peripheral nerves are linked with the dysfunction of neural vasculature. We investigated C-fibers and microvessels of sciatic nerve of normal, DM, and DM + epoetin delta-treated rats. C-fibers immunoreactive for calcitonin gene-related peptide (CGRP), tyrosine hydroxylase (TH), epoetin receptor (EpoR), and common β receptor subunit of the interleukin 3 receptor (IL-3Rβ) were present in all rats, whereas in DM and epoetin-treated rats C-fibers also showed neuronal (nNOS) and inducible (iNOS) nitric oxide synthases. The cross-sectional area of CGRPpositive C-fibers was decreased in DM, but it recovered after epoetin treatment. In all conditions, vascular endothelium showed scarce immunolabeling for endothelial nitric... Pediatric Obesity Etiology, Pathogenesis, and Treatmentseries:Contemporary EndocrinologyChildhood obesity and its co-morbidities -- including type 2 diabetes, hypertension, dyslipidemia, sleep apnea, and fatty liver disease -- have seen striking increases in recent years. Despite a wealth of investigation, there is considerable controversy regarding the etiology of childhood obesity and the optimal approaches for prevention and treatment. Pediatric Obesity: Etiology, ... (Source: Springer Medicine titles) Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy Cardiac-type sarco(endo)plasmic reticulum Ca2-ATPase (SERCA2a) plays a major role in cardiac muscle contractility. Phospholamban (PLN) regulates the function of SERCA2a via its Ser16-phosphorylation. Since it has been proposed that the Ser/Thr residues on cytoplasmic and nuclear proteins are modified by O-linked N-acetylglucosamine (O-GlcNAc), we examined the effect of O-GlcNAcylation on PLN function in rat adult cardiomyocytes. Studies using enzymatic labeling and co-immunoprecipitation of wild type and a series of mutants of PLN showed that PLN was O-GlcNAcylated and Ser16 of PLN might be the site for O-GlcNAcylation. In cardiomyocytes treated with O-(2-acetamido-2-deoxy-d-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc), the O-GlcNAcylation was significantly increased compared to no... Losing weight may pollute the blood Weight loss releases chemical pollutants into the blood, which can stick around, increasing the risk of diabetes, cancer and dementia (Source: New Scientist - Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Diabetes education programme cost effective in UK (Source: PharmacoEconomics and Outcomes News) Concern over diabetes drug sales Concerns have been raised after a diabetes drug that was urged to be withdrawn from sale more than two months ago remains available (Source: Nursing in Practice) Erectile dysfunction common in Chinese men with Type 2 diabetes Erectile dysfunction affects three-quarters of Chinese men with Type 2 diabetes, say researchers who add that the majority of such men can be successfully treated with sildenafil citrate. (Source: MedWire News - Diabetes) The role of PPAR?in pancreatic cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus This article will review the mechanisms by which PPAR?activation acts to maintaincell function and survival in Type 2 diabetes mellitus and highlight some of the current controversies in this field. (Source: Diabetes, Obesity and Metabolism) Drug withdrawal advice unheeded A recommendation from the British Medical Journal (BMJ) to withdraw a popular diabetes drug has gone unheeded for two months despite concerns the drug may raise the risk of heart attacks (Source: Pharmacy Europe)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Gender differences in the effects of streptozotocin-induced diabetes on parasympathetic vasodilatation in the rat submandibular gland Conclusions: Parasympathetic vasodilatation in the rat submandibular gland is diminished equally in diabetic males and females. However, in males diabetes predominantly impairs PGI2- and NO-dependent vasodilatation, whereas in females the contribution of EDHF-mediated pathways are affected and NO-dependent vasodilatation is preferentially maintained. (Source: Archives of Oral Biology) Erectile dysfunction common in Chinese men with Type 2 diabetes Erectile dysfunction affects three-quarters of Chinese men with Type 2 diabetes, say researchers who add that the majority of such men can be successfully treated with sildenafil citrate. (Source: MedWire News - Hypertension) Rosiglitazone: a cautionary tale (Source: BMJ Online First) Study finds more Americans bypassing their personal physician when immediate treatment required (Emory University) Only 45 percent of the 354 million annual visits for acute care in the United States are made to patients' personal physicians, as Americans increasingly make busy emergency departments, specialists or outpatient care departments their first point of contact for treatment of new health problems or a flare up of a chronic condition like asthma or diabetes. (Source: EurekAlert! - Medicine and Health) Researchers at UC Riverside find solution to cell death problem vexing stem cell research (University of California - Riverside) Researchers at the University of California, Riverside, have found that a chemically synthesized compound, blebbistatin, can help prevent cell death in human pluripotent stem cells. These cells are of interest to stem cell scientists working on finding therapies for spinal cord injuries, Parkinson's disease, burns, heart disease, diabetes, arthritis, and other ailments. Another advantage of using blebbistatin, say the researchers, is that no human- or animal-derived materials is needed for coating the culture surfaces. (Source: EurekAlert! - Medicine and Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Bariatric operations reduce odds of gestational diabetes, cesarean section (Weber Shandwick Worldwide) Obese women who have bariatric surgical procedures before pregnancy were three times less likely to develop gestational diabetes than women who have bariatric operations after delivery, according to new research findings published in the August issue of the Journal of the American College of Surgeons. (Source: EurekAlert! - Medicine and Health) Short sleepers at higher risk of diabetes and heart disease (University of Warwick) People who sleep less than six hours a night may be three times more likely to develop a condition which leads to diabetes and heart disease, according to researchers at the University of Warwick. (Source: EurekAlert! - Medicine and Health) Premier issue of new Childhood Obesity journal launched by Mary Ann Liebert Inc., publishers (Mary Ann Liebert, Inc./Genetic Engineering News) Publisher Mary Ann Liebert announced the launch of Childhood Obesity providing physicians, nurses, dietitians, diabetes educators, nutritionists, psychologists, educators and school nurses, community organizers, and policymakers with effective prevention and treatment strategies that promote environmental and policy changes, patient education and motivation tools, and clinical advances in the field. The journal, an outgrowth of Obesity and Weight Management, has a broad mission to be the premier journal and central forum on childhood and adolescent obesity. (Source: EurekAlert! - Medicine and Health) The Effect of Features of the Metabolic Syndrome on Atherosclerotic Risk in Relatively Long-Surviving Patients with Type 1 Diabetes Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders) Effect of Subcutaneous Glucose Sensor Implantation on Skin mRNA Expression in Pigs Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Risk Factors for Microvascular Complications of Diabetes Among South Indian Subjects with Type 2 Diabetes?The Chennai Urban Rural Epidemiology Study (CURES) Eye Study-5 Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology) UK watchdog calls for Glaxo's Avandia recall UK regulators call for the withdrawal across Europe of GlaxoSmith-Kline's diabetes drug Avandia (Source: FT.com - Drugs and Healthcare) Diabetes and poor glycemic control increase HF risk in CAD patients Results from the Heart and Soul Study show that patients with stable coronary artery disease (CAD) who have diabetes are at increased risk for developing heart failure (HF) compared with nondiabetics with CAD. (Source: MedWire News - Diabetes) Smoking and obesity critical to controlling diabetes levels Report shows improvement in diabetics? health with primary care, writes JOANNE HUNT (Source: The Irish Times - Health) Kardiomiopatia rozstrzeniowa i przerostowa u pÅ‚odu matki z cukrzyca ciezarnych - opis przypadku. We report a case of hypertrophic cardiomyopathy preceded with dilated cardiomyopathy in a fetus of a diabetic mother. The fetal echocardiography at the 23rd week of gestation revealed signs of dilated cardiomyopathy with signs of cardiac failure. Under the echocardiographic monitoring the successful treatment was performed. In spite of poor prognosis, the child was born at the 39th gestation week in a good condition. PMID: 20813091 [PubMed - as supplied by publisher] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> [The importance of case reports in current pediatric endocrinology and metabolism literature - the analysis of publications indexed in Medline in the years 2004-2009.] Conclusion: Case reports remain an important contribution to the pediatric literature, mainly fulfilling an essential role in providing information about new medical problems. Medical literature published in Polish is relatively rich in clinical case reports. Publishing a case report in field of endocrinology and metabolism in Pubmed indexed journal is considered reasonable in situations where a new medical condition is being presented (most often a new mutation), a novel therapy has been discovered, the case is interesting or where the publishing of such reports fulfils didactic/educational needs. PMID: 20813090 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism) [Endocrine disorders in children after treatment for brain tumors.] Authors: Krawczuk-Rybak M Endocrine dysfunction is one of the most common late effect of anticancer treatment. The kind and degree of the disorder depend on tumor location, therapy, especially on the dose of radiotherapy, different sensitivity of the hypothalamo-pituitary axes to irradiation, as well as on the time of treatment. The growth hormone secretion axis is the most vulnerable part, and growth disorders occure most frequently (after a total dose of >30 Gy); then, after a total dose of 50-60 Gy: gonadotropin, ACTH deficiency, and, rarely, TSH deficiency. Spinal irradiation leads to the height loss and disproportionate growth as well as dysfunction of gonads and thyroid gland. Chemotherapy (alkylating agents) deteriorates gonadal function. The recognition, good and early diagn... [The role of FTO gene polymorphism in the pathogenesis of obesity.] Authors: Tercjak M, LuczyÅ„ski W, Wawrusiewicz-Kurylonek N, Bossowski A Both environmental and genetic factors play a role in the pathogenesis of obesity. At present, researchers are examining the genetic background of overweight. Over 100 genes are suspected to influence the obesity. One of those genes is FTO (fat mass and obesity-associated gene). In the manuscript, the relationship between FTO gene polymorphism (AA allele) and overweight, obesity and their consequences are discussed. It was proved, in studies on large number of people, that FTO gene polymorphism is related to higher body mass index, weight and abdominal circumference. Some authors showed that FTO gene polymorphism influences the food intake, energy expanditure and insulin resistance. The expression of FTO gene pro... [Evaluation of mental development of children with congenital hypothyroidism detected in screening test - personal observations.] Conclusions: 1. Mental development of the studied children with CH was within normal range. 2. Out of all measured parameters determining mental development, tasks in mathematics, analysis and synthesis, visual concentration and concentration on the hearing level had worst results. 3. The level of TSH in the screening test had no effect on the mental development of children with CH. 4. Out of all environmental factors, parental education influenced the mental development of the studied children. PMID: 20813087 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism) Budowa somatyczna oraz zdolność zachowania równowagi dynamicznej dziewczat uprawiajacych gimnastyke artystyczna. Conclusion: Body constitution type in the qualified gymnasts is characterised by the prevalence of the ectomorphic component. The study results indicate that female gymnasts are generally slim and lean. It is necessary to monitor BMI in order to exclude weight-related disorders and to observe the changes with age. The poorest result was found when the gymnasts bent in the backward direction as this body position is most difficult to assume and to maintain body equilibrium as compared to all other directions. PMID: 20813086 [PubMed - as supplied by publisher] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> [Agility in treatment of children with type 1 diabetes - pilot study.] This study showed that an interesting physical activity resulted in a more eager and systematic effort among examined diabetic children. Its proper organization in time may help in the metabolic control in children with type 1 diabetes. PMID: 20813085 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism) [Overweight, obesity and metabolic syndrome in children with type 1 diabetes melllitus.] Conclusions: The population of children with type 1 diabetes is characterized by high frequency of overweight/obesity, abdominal obesity, dyslipidemia and hypertension. The features of metabolic syndrome are less frequent. It is worthwhile to monitor the risk for development of cardiovascular diseases in this group of children. PMID: 20813084 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism) L-karnityna obniza stres oksydacyjny indukowany eksperymentalnym niedotlenieniem hypobarycznym. Conclusion: This study suggests that the administration of L-carnitine can be beneficial in attenuating the oxidative stress associated with exposure to high altitude. PMID: 20813083 [PubMed - as supplied by publisher] (Source: Pediatric Endocrinology, Diabetes, and Metabolism) [Optimization of monogenic diabetes screening programme - initial report on recruitment efficacy of the TEAM project.] Conclusions: Periodic reevaluation of patients' data allows a significant increase in the number of candidates subjected to genetic screening and potentially achieving beneficial therapeutic effects by means of pharmacogenetics. PMID: 20813082 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism) [Evaluation of preserved insulin secretion in children and adolescents with type 1 diabetes.] Conclusion: Repeated measures of c-peptide can enable us to define two groups of patients with immune-mediated diabetes with different levels of disease and metabolic control. PMID: 20813081 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Engaging community pharmacists in the primary prevention of cardiovascular disease: protocol for the Pharmacist Assessment of Adherence, Risk and Treatment in Cardiovascular Disease (PAART CVD) pilot study This study will be a longitudinal pre- and post-test pilot study with a single cohort of up to 100 patients in ten pharmacies. Patients aged 50-74 years with no history of heart disease or diabetes, and taking antihypertensive or lipid-lowering medicines, will be approached for participation. Assessment of cardiovascular risk, medicines use and health behaviours will be undertaken by a research assistant at baseline and following the intervention (6 months). Validated interview scales will be used where available. Baseline data will be used by accredited medicines management pharmacists to generate a report for the treating community pharmacist. This report will highlight individual patients' overall CVD risk and individual risk factors, as well as identifying modifiable health behaviours ... Licensing process for top selling diabetes drug under fire Doctors should demand more rigorous proof of long term risks and benefits for diabetes drugsRelated items from OnMedicaAntihypertensive drugs vary in heart attack riskRisk/benefit balance of alteplase shifts quicklyCare homes drug error rate raises concernsFake medicine warning hits cinemasBenefits of statins 'still outweigh risks' (Source: OnMedica Latest News) Associations of Fetuin-A levels with vascular disease in type 2 diabetes patients with early diabetic nephropathy Conclusions: The results of this cross-sectional study suggest that lower fetuin-A levels are associated with macrovascular late complications in high-risk type 2 diabetes patients while there are no associations of fetuin-A with metabolic status or microvascular complications. (Source: Cardiovascular Diabetology) MHRA issues advice and information on the use of rosiglitazone (Avandia®, Avandamet®) in the treatment of diabetes and related BMJ commentaries Source: MHRA, BMJ, BBC Area: News Following the broadcast of the BBC Panorama programme on rosiglitazone (Avandia®) and concerns over its cardiovascular safety, the MHRA has issued a reminder that there is an ongoing Europe-wide review of the drug's risks and benefits and that it is contributing to current EU assessment of rosiglitazone which is anticipated to reach its conclusion within the next month. The Agency reiterates that "while the European review is ongoing, healthcare professionals are reminded to closely observe the current contraindications and monitoring requirements for rosiglitazone, and to consider alternative treatments where appropriate." Further information for healthcare professionals (CAS communication July 2010) and patients (Q&A document) can be accessed from ... Sibutramine treatment increases risk of cardiovascular outcomes in high-risk patients Source: New England Journal of Medicine Area: News The New England Journal of Medicine has published the results of the SCOUT (Sibutramine Cardiovascular Outcomes Trial) study, which prompted the review by the EMEA earlier this year resulting in suspension of its European Marketing Authorisation. SCOUT aimed to determine the long-term effects of sibutramine on rates of cardiovascular events and cardiovascular death in patients at high cardiovascular risk. Participants were overweight or obese, aged 55 or older, with pre-existing cardiovascular disease, type 2 diabetes mellitus, or both. They were randomised to treatment with sibutramine or placebo in addition to a weight management programme. Primary end point was the time from randomisation to the first occurrence of a primary...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Engineered skin heals foot ulcers fastest Miami — A new study suggests that “engineered skin” &emdash; or bilayered living-cell therapy (Apligraf, Organogenesis) — significantly improved healing of diabetic foot ulcers compared with other advanced biologic therapies, MedPage Today reports. (Source: Modern Medicine) Vascular Effects of Ultrafine Particles in Type 2 Diabetics Conclusions: Inhalation of elemental carbon ultrafine particles for 2 hr transiently activated platelets, and possibly the vascular endothelium, in people with type 2 diabetes. (Source: EHP-in-Press) Sleep deficiency and Diabetes This study found a link between sleep and developing diabetes or pre-diabetes. However, studies like these should be of value to those of us already with diabetes because they reveal how complicated this disease is and how we need to think of management in broader terms. We are complicated biological creatures. Diabetes is influenced by various hormonal systems which are in turn influenced by all sorts of stimuli. There is a need to look at ourselves in a holistic way and care for ourselves. In other words, we need to consider our bodies, minds, emotions, lives, stressors, environment - the list could go on. According to the study, getting less than 6 hours of sleep a night increases the likelihood of developing diabetes and heart disease. The researchers looked at data from 1,455 partic... Medical Journal Urges U.K. to Pull Avandia The British Medical Journal said diabetes drug Avandia should be withdrawn from sale. But GlaxoSmithKline said it has extensive documentation of the drug's benefits. (Source: WSJ.com: Health) U.K. Medical Journal Questions Avandia License The British Medical Journal said GlaxoSmithKline's diabetes drug should never have been licensed and should be withdrawn from sale, a claim the company rejected. (Source: WSJ.com: Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> British regulators want Avandia diabetes pill pulled British drug regulators say GlaxoSmithKline's controversial diabetes pill Avandia should be pulled from the U.K. market because of concerns that ... (Source: USATODAY.com Health) U.K. Medical Journal Says GSK's Avandia Should Be Pulled The British Medical Journal said GlaxoSmithKline's diabetes drug should never have been licensed and should be withdrawn from sale, a claim the company rejected. (Source: WSJ.com: Health) Concern About Rosiglitazone (Avandia) And How Drugs Are Regulated And Promoted, BMJ There is serious concern about top-selling diabetes drug rosiglitazone (Avandia), its safety, as well as the whole system by which medications are regulated, evaluated and promoted worldwide, according to a BMJ (British Medical Journal) investigation. Dr. Fiona Godlee, BMJ Editor-in-Chief, thinks Avandia should not have been licensed; she believes it should be withdrawn. There should be better access to raw data used to license drugs, as well as more robust regulatory processes, to allow examination by the scientific community, Godlee added... (Source: Health News from Medical News Today) MHRA under pressure to withdraw rosiglitazone The UK drug regulator has come under fire for failing to act on an expert recommendation to withdraw the type 2 diabetes drug rosiglitazone. (Source: Pulse) Behavioral control is an important predictor of soy intake in adults in the USA concerned about diabetes. Authors: Li S, Camp S, Finck J, Winter M, Chapman-Novakofski K The primary objective of this study was to determine the variables associated with intention to consume soy products and identify key variables that could be used as targets in soy nutrition education and consumption promotion. A pre/post-test survey was used during a three session class focused on diabetes that discussed and introduced soy foods. The Theory of Planned Behavior framed the questions and variables examined. Subjective norms and behavioral control were most important in predicting intention to consume soy foods. Specifically, health experts and providers were important subjective norms; accessibility and ability to prepare were key behavioural control determinants. While most participants tried soy during the ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Short Nighttime Sleep Duration Among Infants, Young Children Associated with Obesity in Later Life September 6, 2010 (EurekAlert) - nsufficient amounts of nighttime sleep among infants and preschool-aged children may be a significant risk factor for developing childhood obesity, according to a report in the September issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals. Additionally, napping does not appear to be an adequate substitute for nighttime sleep in terms of preventing obesity. read more (Source: Diabetes News from dLife.com) Inflammation is Associated with Lower Intelligence and Premature Death September 6, 2010 (EurekAlert) - Inflammation is associated with lower intelligence and premature death, according to Swedish scientists from the Karolinska Institute in Stockholm, Sweden. ?Those with low-grade inflammation performed more poorly on standardised intelligence tests, even after excluding those with signs of current illness. Inflammation also predicted an increased risk of premature death,? said lead researcher Dr Hakan Karlsson. read more (Source: Diabetes News from dLife.com) What Are Babies Made Of? Research Shows for Some It Is Sugar, Salt and Not All Things Nice September 6 2010 (EurekAlert) - Children as young as four weeks old are being fed a poor diet of biscuits, ice-cream and soft drinks, according to new Australian research. A study published in the journal Nutrition & Dietetics found some month-old babies had been introduced to high fat, salt and sugar foods, despite health authorities recommending exclusive breastfeeding to six months of age. read more (Source: Diabetes News from dLife.com) Commentary: What can we learn from the continuing regulatory focus on the thiazolidinediones? (Source: BMJ Online First) Rosiglitazone: what went wrong? (Source: BMJ Online First)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Licensing drugs for diabetes (Source: BMJ Online First) International Study Led By VA-Harvard Physician Yields Insight On Risks From Fatty Arteries This study was an impressive international collaboration that may hold important clinical benefits for Veterans and others with cardiovascular disease," said VA Secretary Eric K. Shinseki... (Source: Health News from Medical News Today) Avandia Weighing up the benefits and risks of diabetes drug Avandia (Source: BHF National News) Heart news digest Diabetes drug, teeth brushing, Roman walk and a special 18th (Source: BHF National News) Now you can raise money for SfE! We’ve teamed up with the website JustGiving to enable you to donate and raise money for SfE online. JustGiving provides you with the tools to set up your own fundraising activities, including an easy to manage online sponsorship form, and it automatically reclaims GiftAid and sends the funds raised straight through to us. The funds raised will go towards the Society for Endocrinology’s activities in medical research, clinical practice and education. You can create a fundraising page for anything – drinking a gallon of milk for osteoporosis, eating a diabetic diet for a month, or reciting John F. Kennedy’s speeches for Addison’s disease - ask not what your hormones can do for you, but what you can do for your hormones! Go to www.justgiving.com/endocrinology...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Diabetes drug still available despite suspension advice (BBC News Online, 6 September 2010) Despite concerns due to reportedly raised risks of heart attack and heart failure, the type 2 diabetes drug Avandia (generic name rosiglitazone) is still being widely prescribed in the UK. Full article (Source: Society for Endocrinology) Portal inflammation is associated with advanced histological changes in alcoholic and non-alcoholic fatty liver disease Conclusions Portal inflammation is a common component of histological spectrum of both AFLD and NAFLD. In both conditions portal inflammation is associated with clinical and histological features suggestive of advanced disease. (Source: Journal of Clinical Pathology) Uganda: Teso Diabetics Ask for Hospital Diabetes patients in Teso sub-region have asked the Government to construct a hospital which will treat and monitor the disease. (Source: AllAfrica News: Health and Medicine) Dangerous diabetes drug still prescribed despite warnings People with diabetes are still being prescribed a potentially dangerous drug two months after safety experts recommended it should be taken off the market. (Source: Nursing Times Breaking News) Uganda: Country Joins War Against Diabetes Uganda will be one of the first countries to benefit from a master plan to fight diabetes in Africa. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Vended Foods And Beverages May Be Linked To Obesity, Diabetes And Coronary Artery Disease School children who consume foods purchased in vending machines are more likely to develop poor diet quality - and that may be associated with being overweight, obese or at risk for chronic health problems such as diabetes and coronary artery disease, according to research from the University of Michigan Medical School. The study also looked at foods sold in school stores, snack bars and other related sales that compete with USDA lunch program offerings and found that these pose the same health and diet risks in school-aged children... (Source: Health News from Medical News Today) Stem Cell Ruling Halts Sight-Saving Research The Association for Research in Vision and Ophthalmology (ARVO), a professional organization of member scientists, opposes the Federal District Court injunction that froze federal funding for human embryonic stem cell (hESC) research. ARVO is troubled by this barrier to research that has the potential to restore sight and mitigate eye damage. ARVO members investigate hESC therapies for treating diseases such as age-related macular degeneration (AMD), diabetic retinopathy, glaucoma and corneal disease, along with studies related to eye tissue transplantation, regeneration and engineering... (Source: Health News from Medical News Today) Diabetes drug Avandia still being prescribed despite heart risk fears A popular diabetes drug is still being prescribed two months after a safety body recommended its withdrawal amid concerns the drug can increase the risk of heart attacks. (Source: Telegraph Health) Heart attack risk of diabetes drug: Experts call for Avandia to be withdrawn A diabetes drug taken by up to 100,000 patients increases the risk of heart attacks and should be withdrawn on safety grounds, senior doctors say today. (Source: the Mail online | Health) Most diabetics need better BP control to reach targets Belgian researchers report that only 16% of patients with Type 2 diabetes achieve the target blood pressure of 130/80 mmHg recommended by American and European regulatory bodies such as the European Society of Hypertension. (Source: MedWire News - Hypertension)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Fish Oil?s Magic Revealed (Ivanhoe Newswire) ? Fish oil was deemed the ?miracle food of the 21st century? because of its anti-inflammatory and anti-diabetes benefits, among many others. (Source: Medical Headlines From Ivanhoe.com) BMJ report into top-selling diabetes drug raises concerns about the drug regulatory system (BMJ-British Medical Journal) A BMJ investigation into the top-selling diabetes drug rosiglitazone (Avandia) raises concerns about its safety and the whole system by which drugs are evaluated, regulated, and promoted around the world. (Source: EurekAlert! - Medicine and Health) Saxagliptin: A dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes mellitus. Conclusion Saxagliptin, a DPP-4 inhibitor approved for the treatment of type 2 diabetes, demonstrated safety and efficacy in lowering HbA(1c), FPG, and PPG levels as both monotherapy and in combination with other oral antidiabetic medications. PMID: 20811029 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP) Use of concentrated insulin human regular (U-500) for patients with diabetes. Conclusion U-500 insulin is efficacious and safe for patients with type 2 diabetes who require a high dosage of insulin to control hyperglycemia. However, health care professionals should be well educated and vigilant about patient safety issues regarding the drug's prescription, dosing, and administration. PMID: 20811030 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP) GlaxoSmithKline responds to British Medical Journal article regarding Avandia® (rosiglitazone) GlaxoSmithKline (GSK) continues to work in the best interest of diabetes patients who face this chronic and serious disease. Patients taking Avandia should speak with their doctor about their treatment and any questions they may have regarding their medicine. (Source: GSK news)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Doctors still prescribe diabetes drug despite heart attack warning A POPULAR diabetes drug is still being prescribed, two months after a safety body recommended its withdrawal amid concerns the drug can increase the risk of heart attacks. (Source: Scotsman.com News - Health) Children with Type 1 diabetes have early signs of atherosclerosis Study results show that children with Type 1 diabetes have significantly increased carotid intima media thickness, an early sign of atherosclerosis, compared with their nondiabetic peers. (Source: MedWire News - Diabetes) Diabetes drug advice 'not heeded' A type two diabetes drug is still being prescribed in the UK two months after it is recommended for withdrawal, Panorama learns. (Source: BBC News | Health | UK Edition) UK wants GSK's Avandia pulled as EU reviews safety LONDON (Reuters) - GlaxoSmithKline's diabetes drug Avandia should be pulled from sale because of concerns about heart risks, British drug regulators said on Monday ahead of a special European meeting on the drug's safety. (Source: Reuters: Health) BBC Panorama report on rosiglitazone Source: BBC Health Area: News In a programme due to air tonight, BBC Panorama reports that rosiglitazone (Avandia®) is still being prescribed widely in the UK for type 2 diabetes, despite concerns over its cardiovascular safety. The EMEA is currently undertaking a benefit-risk review of rosiglitazone-containing medicines - the CHMP is meeting this week (8th September) to discuss the ongoing review which is expected to be finalised at its next meeting (20-23rd September 2010). According to a BBC Health report, an expert panel at the MHRA voted unanimously in July 2010 for the withdrawal of rosiglitazone from the UK; this recommendation was not however made public. The Agency released a letter to healthcare professionals at this time outlining current pre...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Increased expression and local accumulation of the prion protein, Alzheimer Abeta peptides, superoxide dismutase 1, and Nitric oxide synthases 1 & 2 in muscle in a rabbit model of diabetes Conclusions: The present study provides evidence that several classic amyloid and oxidative stress-related disease proteins coordinately increase in overall expression and form localized accumulations in diabetic muscle. The present study highlights the capacity of this wild-type animal model to produce an array of hallmark pathological features that have been also been described in other muscle diseases. (Source: BMC Physiology - Latest articles) Children Who Eat Vended Foods Face Health Problems, Poor Diet School children who consume foods purchased in vending machines are more likely to develop poor diet quality - and that may be associated with being overweight, obese or at risk for chronic health problems such as diabetes and coronary artery disease, according to research from the University of Michigan Medical School. The study also looked at foods sold in school stores, snack bars and other related sales that compete with USDA lunch program offerings and found that these pose the same health and diet risks in school-aged children... (Source: Health News from Medical News Today) Insulin pump therapy inequality There are major inequities in access to insulin pump therapy among patients with type 1 diabetes, according to a recent survey. (Source: Nursing Times Breaking News) Stem cell clinics: experts insist claims of cure-all are medically unproven Health tourists travel the world and spend thousands, but their hopes of being cured are likely to be dashedFor the past decade stem cells have sparked huge excitement among scientists, dramatic media coverage about breakthroughs that could mean a cure for some of the nastiest diseases, and hope ? sometimes desperate ? among patients that the reality will match the hype. That has fuelled a booming trade in stem cell tourism ? people heading to clinics abroad and forking out large sums for what are called stem cell treatments but which are unlikely to work and possibly do harm.It is, as some of the UK's leading stem cells experts warned last week, a world of unproven therapies, patient optimism and predatory clinicians. Despite the lack of reliable evidence underpinning the treatments... Justin Webb: 'I have to believe in miracles' The 'Today' presenter Justin Webb, whose son suffers from diabetes, explains how he was brought close to tears by an item on stem-cell treatment (Source: Telegraph Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Why fish oils work swimmingly against inflammation and diabetes Researchers have identified the molecular mechanism that makes omega-3 fatty acids so effective in reducing chronic inflammation and insulin resistance. (Source: ScienceDaily Headlines) Forecasting: Patient Flow Modeling Comes Of Age - Pre-Summit Workshop October 5th Boston Judith Kulich, Associate Principal, and Emily Jin, Manager, at ZS Associates talk to eyeforpharma about how patient flow modeling can inform forecasting. Patient flow, or system dynamics forecasting is a common approach for modeling situations in which patient potential is affected by movement between disease states. The technique is used frequently in oncology, diabetes, RA, and other markets with lines of therapy dynamics... (Source: Health News from Medical News Today) Increased Risk of Death with Tygacil (Tigecycline) Compared to Other Antibiotics Used to Treat Similar Infections Source: Food and Drug Administration Related MedlinePlus Pages: Antibiotics, Diabetic Foot, Pneumonia (Source: MedlinePlus Health News) Key to fish oil "magic" found The mystery of how fish oil helps fight diabetes and heart disease may have been solved (Source: Nursing in Practice) Beta-1 adrenergic receptor polymorphism may increase LVH risk. The Arg389 polymorphism of the beta-1 adrenergic receptor is associated with a higher risk for left ventricular hypertrophy than is the Gly389 polymorphism in non-diabetic acute myocardial infarction survivors, researchers report. (Source: MedWire News - Diabetes)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Treating Diabetes With Severe Personality-Disordered Individuals and Families Diabetes is an increasingly common chronic medical condition that affects not only patients but also their families. Ensuring adherence to a treatment regimen in diabetic patients is particularly challenging for physicians as well as counselors providing health-focused counseling. However, that challenge is exponentially increased when the patient and one or more family members manifest personality-disordered behavior that interferes with and complicates diabetic treatment. Diabetes as a chronic medical condition is described in the context of individual and family borderline dynamics. (Source: The Family Journal) Mouse Study May Help Explain Fish Oil?s Benefits Giving rodents omega-3 fatty acids helped counteract inflammation that can lead to diabetes (Source: The Doctors Lounge - Health News) Mouse Study May Help Explain Fish Oil's Benefits Giving rodents omega-3 fatty acids helped counteract inflammation that can lead to diabetes Source: HealthDay Related MedlinePlus Pages: Diabetes, Dietary Fats (Source: MedlinePlus Health News) The Skeletal Subsystem as an Integrative Physiology Paradigm Abstract Homeostatic bone remodeling depends on precise regulation of osteoblast-osteoclast coupling through intricate endocrine, immune, neuronal, and mechanical factors. The osteoblast-osteoclast model of bone physiology with layers of regulatory complexity can be investigated as a component of a local skeletal subsystem or as a part of a complete whole-body system. In this review, we flip the traditional investigative paradigm of scientific experimentation (?bottom?top research?) to a ?top?bottom? approach using systems biology. We first establish the intricacies of the two-cell model at the molecular signaling level. We then provide, on a systems level, an integrative physiologic approach involving many recognized organ-level subsystems having direct and/or... Differential Diagnosis of Hereditary Nephrogenic Diabetes Insipidus with Desmopressin Infusion Test Conclusion It is concluded that the desmopressin infusion test is a simple and reliable method for the diagnosis and differential diagnosis of HNDI in early childhood. Content Type Journal ArticleDOI 10.1007/s12098-010-0181-3Authors Zelal Bircan, Department of Pediatric Nephrology, Kocaeli University School of Medicine, Kocaeli, TurkeyHatice Mutlu, Department of Pediatrics, Kocaeli University School of Medicine, Kocaeli, TurkeyHae Il Cheong, Department of Pediatrics, Seoul National University Children?s Hospital and Kidney Research Institute, Seoul, Korea Journal Indian Journal of PediatricsOnline ISSN 0973-7693Print ISSN 0019-5456 (Source: Indian Journal of Pediatrics)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice This study investigated the preventive effects of KP on obesity and its downstream symptoms (various metabolic disorders) using Tsumura, Suzuki, Obese Diabetes (TSOD) mice, a multifactorial genetic disease animal model in which metabolic diseases develop spontaneously, similar to metabolic syndrome in humans, and Tsumura, Suzuki, Non-Obesity (TSNO) mice as the corresponding control mice. When feed that was mixed with KP (1 or 3%) was given ad libitum to TSOD and TSNO mice for 8 weeks, body weight increase, visceral fat accumulation, lipid metabolism abnormalities, hyperinsulinemia, glucose intolerance, insulin resistance, hypertension, and peripheral neuropathy were suppressed in TSOD mice, but no marked differences were observed in TSNO mice. Because KP had preventive effects o... Ginkgo biloba extract enhances glucose tolerance in hyperinsulinism-induced hepatic cells Abstract Ginkgo biloba, an herbal medication, is capable of lowering glucose, fat, and lipid peroxide in diabetic patients. In the current study, we tested the hypothesis that Ginkgo biloba extract (GBE) prevented hyperinsulinism-induced glucose intolerance in hepatocytes. We investigated the effects of GBE on glucose consumption, glucokinase activity, and mRNA levels of key genes in glucose metabolism and the insulin signaling pathway. To better show its efficacy, we included a control group that was treated with rosiglitazone, a type of thiazolidinedione (TZD). The data indicated that GBE repressed glucose uptake under normal conditions, while it dramatically improved glucose tolerance under insulin-resistant conditions. Furthermore, after analyzing gene expression, we ... Long Term Data Presented at ESC 2010 Further Support the Benefit of TheSirolimus Drug-Eluting Stent Compared to The ENDEAVOR(R) Zotarolimus-Eluting Stent in Important High-Risk Subgroups STOCKHOLM, September 2, 2010/PRNewswire/ -- - Additional Analysis of 18 Month Data of the SORT OUT III Trial Provides Detail on Safety and Efficacy Outcomes in Patients With Diabetes, Acute Coronary Syndrome, or Treatment of... (Source: Drugs.com - Clinical Trials) Protein test ups diabetes diagnoses in some races NEW YORK (Reuters Health) - Efforts to adopt a more accurate test for diagnosing diabetes may have hit a snag. Comparing the age-old oral glucose tolerance test to the newer hemoglobin A1c test confirms earlier evidence that race may influence test results, Danish researchers report. (Source: Reuters: Health) Protein Test Ups Diabetes Diagnoses in Some Races Efforts to adopt a more accurate test for diagnosing diabetes may have hit a snag. Comparing the age-old oral glucose tolerance test to the newer hemoglobin A1c test confirms earlier evidence that race may influence test results, Danish researchers report.Source: Reuters Health Related MedlinePlus Pages: Diabetes, Laboratory Tests (Source: MedlinePlus Health News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Americans Struggle with Long-Term Weight Loss September 3, 2010 (EurekAlert) - Only about one in every six Americans who have ever been overweight or obese loses weight and maintains that loss, according to Penn State College of Medicine researchers. read more (Source: Diabetes News from dLife.com) Hair Provides Proof of the Link Between Chronic Stress and Heart Attack September 3, 2010 (EurekAlert) - Researchers at The University of Western Ontario have provided the first direct evidence using a biological marker, to show chronic stress plays an important role in heart attacks. Stressors such as job, marital and financial problems have been linked to the increased risk for developing cardiovascular disease including heart attack. But there hasn't been a biological marker to measure chronic stress. Drs. read more (Source: Diabetes News from dLife.com) Enzymatic Function of Two Methylthiotransferase Families [Cell Biology] Bacterial and eukaryotic transfer RNAs have been shown to contain hypermodified adenosine, 2-methylthio-N6-threonylcarbamoyladenosine, at position 37 (A37) adjacent to the 3'-end of the anticodon, which is essential for efficient and highly accurate protein translation by the ribosome. Using a combination of bioinformatic sequence analysis and in vivo assay coupled to HPLC/MS technique, we have identified, from distinct sequence signatures, two methylthiotransferase (MTTase) subfamilies, designated as MtaB in bacterial cells and e-MtaB in eukaryotic and archaeal cells. Both subfamilies are responsible for the transformation of N6-threonylcarbamoyladenosine into 2-methylthio-N6-threonylcarbamoyladenosine. Recently, a variant within the human CDKAL1 gene belonging to the e-MtaB subfamily was... Metformin Might Prevent Colorectal, Lung Cancers The old, cheap diabetes drug metformin is attracting notice as a chemoprevention agent. Medscape Medical News (Source: Medscape Hematology-Oncology Headlines) NIHR Clinical Lecturer in Endocrinology and Diabetes (NTN(A) attached) - University of Sheffield Up to two National Institute for Health Research Clinical Lectureship posts are available at the University of Sheffield offering a programme of integrated training in clinical academic medicine. The posts are open to a number of specialties, endocrinology and diabetes being one, and are available for four years or until the post holder obtains their CCT. They must also have successfully completed a PhD or MD and must be eligible for or in posession of a National Training Number (NTN). The deadline for applications is 5 October 2010. For more information please follow the link below. Further details (Source: Society for Endocrinology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Differential Contribution of Diabetes and the Ren2 Gene to Glomerular Pathology in Diabetic (mREN-2)27 Rats Narrowing the scope of utility for (mREN-2)27 rats may help to create better methods for researching diabetic nephropathy. Laboratory Investigation (Source: Medscape Today Headlines) Fatty acids 'may prevent diabetes' The secret of how fish oil helps prevent heart disease and diabetes is believed to have been unlocked by scientists who now hope to develop new dietary remedies and drugs to reduce conditions such as type-2 diabetes, heart disease and arthritis. (Source: Nursing Times Breaking News) Longitudinal examination of cervical volume and vascularization changes during the antepartum and postpartum period using three-dimensional and power Doppler ultrasound Journal of Perinatal Medicine 38 (5): 461-465 Abstract Objective: To assess longitudinally the changes in cervical volume and vascularization during the peripartum period using three-dimensional ultrasound (3D US) and power Doppler and to determine whether these measures change with gestational complications. Methods: Longitudinal measurements of cervical dimensions by transvaginal 3D US and power Doppler using the virtual organ computer-aided analysis program were performed at 11?14, 22?24, 32?34 weeks' gestation, and at 6 weeks' postpartum in 111 pregnant women. Comparisons were made between women who delivered at term (vs. preterm), nulliparous (vs. parous), with (vs. without) pre-eclampsia and those with (vs. without) gestational diabetes. Results: After establishing reference ... Pcif1 modulates Pdx1 protein stability and pancreatic {beta} cell function and survival in mice The homeodomain transcription factor pancreatic duodenal homeobox 1 (Pdx1) is a major mediator of insulin transcription and a key regulator of the β cell phenotype. Heterozygous mutations in PDX1 are associated with the development of diabetes in humans. Understanding how Pdx1 expression levels are controlled is therefore of intense interest in the study and treatment of diabetes. Pdx1 C terminus–interacting factor-1 (Pcif1, also known as SPOP) is a nuclear protein that inhibits Pdx1 transactivation. Here, we show that Pcif1 targets Pdx1 for ubiquitination and proteasomal degradation. Silencing of Pcif1 increased Pdx1 protein levels in cultured mouse β cells, and Pcif1 heterozygosity normalized Pdx1 protein levels in Pdx1+/– mouse islets, thereby increasing ... How do organisms make dietary choices? When given a choice, organisms will choose a diet that maintains a nutritional balance in tune with their needs. That choice, studied in fruit flies for the first time, is regulated by activity in a molecular pathway involved in aging, cancer and diabetes. Humans share the same molecular pathway. The study, the first to be done in a genetically tractable lab animal, could lead to treatments that would "reboot" metabolic pathways in individuals who are obese or suffer from diabetes. (Source: ScienceDaily Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Children who eat vended snack foods face chronic health problems, poor diet, study finds School children who consume foods purchased in vending machines are more likely to develop poor diet quality -- and that may be associated with being overweight, obese or at risk for chronic health problems such as diabetes and coronary artery disease, according to new research. (Source: ScienceDaily Headlines) An Economic Evaluation of Colesevelam when Added to Metformin-, Insulin- or Sulfonylurea-Based Therapies in Patients with Uncontrolled Type 2 Diabetes Mellitus (Source: PharmacoEconomics) Factor Structure and Measurement Invariance of a 10-Item Decisional Balance Scale: Longitudinal and Subgroup Examination Within an Adult Diabetic Sample (Source: Measurement in Physical Education and Exercise Science) Frequent Reoccurrence of Hypoglycemia in a Type 2 Diabetic Patient with Insulin Antibodies (Source: Molecular Diagnosis) |
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Types Of Diabetes - Type 1, 2 And Gestational By Dr John | |||
Diabetes is a metabolic disease that is caused when the pancreas does not produce enough insulin to naturally turn sugars ingested into your body into energy. There are three major types ofType-1 Diabetes This type of diabetesis an autoimmune disease - which is a result of the body's failure tofight infection. As a result, the body begins to attack its own cells -in this case the beta cells in the pancreas that produce insulin. Thebody destroys the beta cells and no insulin is produced. People withtype-1 have to take insulin shots daily in order to live. Thecauses of type-1 are not known, however autoimmune, genetic,and environmental factors are believed to play a role in the onset oftype-1 diabetes. This type of can affect people of any age,but most often is found in children and young adults. Symptoms oftype-1 include increased thirst and urination, constanthunger, blurred vision, unexplained weight loss, and fatigue. An earlydiagnosis of type-1 is very important. Without dailyinjections of insulin, a person with this type of diabetes is at a high risk of lapsing into a diabetic coma, a life-threatening condition. Type-2 Diabetes This type of diabetesis the most common type. Type-2 usually affects adults who areobese, have a family history of diabetes, or have a Author: Bender, David A.
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]]>Author: Dardevet, D. 1; Moore, M. C. 2; Remond, D. 1; Everett-Grueter, C. A. 2; Cherrington, A. D. 2,*
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]]>Author: Clavel, Thomas 1,2; Dore, Joel 2; Blaut, Michael 1,*
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]]>Author: Bosscher, D. *; Van Loo, J.; Franck, A.
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]]>Author: Bannink, A. 1,*; Dijkstra, J. 2; Koopmans, S.-J. 1; Mroz, Z. 1
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]]>Author: Guilloteau, P. 1,*; Le Meuth-Metzinger, V. 2; Morisset, J. 3; Zabielski, R. 4
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]]>Author: Griffiths, Helen R. 1,*; Grant, Melissa M. 2
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]]>previous history ofgestational diabetes. Type-2 is not caused by the body'sinability to produce insulin, but rather by the body's inability to usethe insulin it creates effectively. This causes the blood to havehigher levels of sugars than normal. The symptoms of type-2diabetes include frequent thirst and urination, nausea, unexplainedweight loss, frequent infections, wounds and sores heal slowly, andfatigue. This type of can often be prevented orcontrolled with certain lifestyle changes, including a healthy diet andregular exercise. Some patients need to take medications and many usenatural treatments to effectively control the symptoms of type-2diabetes. Gestational Diabetes This type ofdiabetes occurs in pregnant women and is caused by an intolerance tocarbohydrates, which causes blood sugar levels to increase. It is veryimportant for a woman who has gestational to control thedisease in order to prevent the baby from being affected at birth. Ifthe blood sugar levels in the pregnant woman are not under control,there is a risk of the baby going into insulin shock at birth. Gestationaldiabetes risk factors include a family history of diabetes, increasedmaternal age, and obesity. While the symptoms of gestational diabetesusually disappear after the birth, there are significant risks to boththe mother and child. The mother is at a higher risk of developingtype-2 at a later time and the child is at a higher risk ofbeing obese or developing later in life. Preventing the Onset of Diabetes Many times, can be prevented or the onset can be delayed. All three types of canbe controlled effectively by changes in your lifestyle. A healthy dietis the most important change - eating healthy foods on a normalschedule allows your body to perform the tasks necessary to sustainlife. A healthy diet should consist of plenty of fresh fruits andvegetables, fiber, and Omega-3 fatty acids. Once a person has beendiagnosed with any type of diabetes, the intake of carbohydrates should be monitored and the intake of sugars should be greatly reduced. Regularexercise is also important for your overall health. Keeping your bodyin good working order by keeping muscles toned and blood flowingcorrectly also helps your body to perform its normal tasks. It isimportant for early diagnosis and effective treatment of inorder to avoid more serious illness and diseases that can be associatedwith such as heart disease and stroke. Diabetics are at ahigher risk of developing many other diseases and illnesses, but themost important thing to remember is that if you work with your body,your body will work for you.
A Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes With Inadequately Controlled Hypertension on an ACEI or ARB and an Additional Antihypertensive Medication
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