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a metabolic disease in which the pancreas fails to produce insulin, a hormone that allows blood sugar to be absorbed by cells for proper function.
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Impact of Childhood Obesity Goes Beyond Health
The health effects of being overweight or obese are well documented. Extra pounds add extra risk for diabetes, heart disease and certain cancers, even among children. But new research also documents significant social and economic consequences of being overweight since high school. (Source: RWJF News Digest - Childhood Obesity)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Diabetes care: Implanted glucose sensor works for more than a year in animal studies
Bioengineers have developed an implantable glucose sensor and wireless telemetry system that continuously monitors tissue glucose and transmits the information to an external receiver. A new article describes the use of this glucose-sensing device as an implant in animals for over one year. After human clinical trials and FDA approval, the device may be useful to people with diabetes as an alternative to finger sticking and short-term, needle-like glucose sensors that have to be replaced every three to seven days. (Source: ScienceDaily Headlines)
Women with gestational diabetes have increased risk of recurrence in subsequent pregnancies, study finds
There is an increased risk of recurring gestational diabetes in pregnant women who developed gestational diabetes during their first and second pregnancies, according to new study. (Source: ScienceDaily Headlines)
Poorly controlled diabetes linked to reduced lung function
Poor glycemic control is associated with reduced lung function in patients with Type 2 diabetes, study results suggest. (Source: MedWire News - Respiratory)
Pharmaceutical drug contamination of waterways threatens life on our planet
This study was the first national-scale evaluation of pharmaceutical drug contamination in streams, and roughly 80 percent of the streams tested were found to be contaminated as well.In 2008, an AP investigation found that at least 46 million Americans are drinking water contaminated with trace amounts of pharmaceuticals. Even though every city tested has its water treated and "purified" prior to being delivered to the public, trace amounts of pharmaceutical drugs are making their way through to the tap. (Since not all major metropolitan areas were tested, the number of people affected is likely far higher than what was reported by AP.)In spite of all this, water quality reports don't disclose the levels of pharmaceuticals found in tap water. Since the EPA and FDA have failed to establish ...
Vitamin D is essential for activating immune system function
(NaturalNews) Researchers have discovered that vitamin D plays a crucial role in activating the immune system's ability to recognize and fight pathogens.While scientists have long known that vitamin D plays a critical role in bone health, recent research has begun to suggest that it also serves to regulate the immune system, helping prevent infection, cancer and autoimmune disorders. Until now, the mechanism by which the vitamin acts on the immune system has been unknown.In a study published in the journal Nature Immunology, researchers from the University of Copenhagen found that when a variety of white blood cells known as a T-cell comes across a pathogen in the bloodstream, it extends a receptor in search of vitamin D. If it encounters the vitamin, the T cell becomes "activated." If the...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
CVD risk rises in line with HbA1c in Type 2 diabetes
Study findings from the Swedish National Diabetes Register show that the risk for cardiovascular disease in people with Type 2 diabetes increases progressively with increasing glycated hemoglobin levels. (Source: MedWire News - Diabetes)
Animal models and biomarkers of neuropathy in diabetic rodents
AS Shaikh, RS SomaniIndian Journal of Pharmacology 2010 42(3):129-134Diabetic neuropathy (DN) is a multifactor complication of diabetes. It is a late finding in type 1 diabetes, but can be an early finding in type 2 diabetes. The cause of DN is still unclear and, like other complications of diabetes, it may be the result of various pathological conditions. Animal models and biomarkers of DN have been extensively used in neuropathic research. The most useful model of DN should exhibit the key feature present in human pathology. Diabetic rodents show behavioral, functional, structural and molecular biomarkers and they are widely used as models to investigate the etiology of DN as well as to screen the efficacy of the potential therapeutic interventions. We have reviewed the different animal ...
Effect of saturated fatty acid-rich dietary vegetable oils on lipid profile, antioxidant enzymes and glucose tolerance in diabetic rats
Conclusion : The type of FA in the dietary oil determines its deleterious or beneficial effects. Lauric acid present in CO may protect against diabetes-induced dyslipidemia. (Source: Indian Journal of Pharmacology)
Irbesartan in experimental diabetic nephropathy
Rajiv Mahajan, Kapil Gupta, Navyug Raj SinghIndian Journal of Pharmacology 2010 42(3):197-197 (Source: Indian Journal of Pharmacology)
Treatment of post-burn neuropathic pain: Evaluation of pregablin
We report our experience with pregabalin for the treatment of post-burn neuropathic pain. A retrospective review of patients treated with pregabalin in a burn outpatient clinic was undertaken. A numerical pain scale was administered to each patient prior to and after treatment to determine efficacy. Side effects and reasons for discontinuation were noted. Out of 24 patients 4 patients were lost to followup, 5 patients discontinued taking pregabalin and 2 patients had incomplete data for evaluation. Of the remaining 13 patients, 69% (11) had a reduction in pain score after treatment. In addition, 2 of the patients who discontinued use had a pain score which decreased to 0. Pregabalin is a well-tolerated, effective means of treating post-burn neuropathic pain. Time to achieve effective dosin...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Removal of Contrast Media From the Coronary Sinus Attenuates Renal Injury After Coronary Angiography and Intervention
Acute renal injury after exposure to radiographic contrast media, contrast-induced nephropathy (CIN), accounts for a substantial proportion of all cases of acute renal failure (). The incremental presence of predisposing factors including pre-existing chronic renal impairment, contrast load, diabetes, and advancing age contribute significantly to the risk of CIN, which may exceed 30% in the highest-risk patients (). Due to common risk factors, patients undergoing coronary angiography or coronary intervention represent a particularly high-risk group. The development of CIN is a major source of clinical concern for several reasons. First, contrast-induced renal injury may in some cases contribute to a permanent worsening of renal function, in some cases requiring temporary or even permanent ...
Genetic markers in diabetes mellitus: the need and promise for specific drug therapies in defined subtypes of diabetes patients
Therapy , July 2010, Vol. 7, No. 4, Pages 309-312. (Source: Future Medicine: Therapy)
Regular Daily Intake of Black Tea Improves Oxidative Stress Biomarkers and Decreases Serum C-Reactive Protein Levels in Type 2 Diabetic Patients
Ann Nutr Metab 2010;57:40–49 (DOI:10.1159/000312666) (Source: Annals of Nutrition and Metabolism)
Selective autophagy regulates various cellular functions
Autophagy is a self-eating system conserved among eukaryotes, in which cellular components including organelles are entrapped into a double membrane structure called the autophagosome and then degraded by lysosomal hydrolases. In addition to its role in supplying amino acids in response to nutrient starvation, autophagy is involved in quality control to maintain cell health. Thus, inactivation of autophagy causes the formation of cytoplasmic protein inclusions, which comprise misfolded proteins and the accumulation of many degenerated organelles, resulting in liver injury, diabetes, myopathy and neurodegeneration. Furthermore, although autophagy has been considered nonselective, increasing evidence points to the selectivity of autophagy in sorting vacuolar enzymes and removal of aggregate-...
Disease management changes course to improve its outcomes
When disease management began, it just entailed a series of programs with a singular focus. Whether
you had asthma, coronary artery disease, heart failure, diabetes or COPD, disease management programs managed only
one chronic illness at a time. (Source: Managed Healthcare Executive Magazine Online)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Antioxidant enzymatic defense in salivary glands of streptozotocin-induced diabetic rats: a temporal study
In this study, we analyzed the antioxidant enzymatic defense and the lipid peroxidation of rat salivary glands in six different periods of diabetic condition. Ninety-six rats were divided into 12 groups: C7/14/21/28/45/60 (non-diabetic animals) and D7/14/21/28/45/60 (diabetic animals). Diabetes was induced by streptozotocin and the rats were euthanized after 7, 14, 21, 28, 45, or 60 days. Their parotid (PA) and submandibular (SM) glands were removed soon after the sacrifice and the total protein and malondialdehyde (MDA) concentrations, as well as, the superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities were determined. Twenty-one days after the diabetes induction, the SM glands showed an increase in SOD, CAT, and GPx activities, as well as, MDA concentr...
Sensor implant monitors blood sugar
An implantable sensor that continuously monitors glucose levels has worked for more than a year in a pig, raising hopes for use in human diabetics, researchers report. (Source: CBC | Health)
Why Fad Diets Work Well for Some, But Not Others
July 28, 2010 (EurekAlert) - Ever notice some people seem to eat anything they want and never gain a pound, while others seem to gain weight just by looking at fattening foods? You may be seeing things correctly after all. According to research published in the July 2010 issue of Genetics, this may have a biological cause.
read more (Source: Diabetes News from dLife.com)
Why Fad Diets Work Well for Some, But Not Others
July 28, 2010 (EurekAlert) - Ever notice some people seem to eat anything they want and never gain a pound, while others seem to gain weight just by looking at fattening foods? You may be seeing things correctly after all. According to research published in the July 2010 issue of Genetics, this may have a biological cause.
read more (Source: Diabetes News from dLife.com)
Diabetic KK-Ay mice are highly susceptible to oxidative hepatocellular damage induced by acetaminophen
In this study, therefore, we investigated acetaminophen-induced liver injury in KK-Ay mice, an animal model of metabolic syndrome. Twelve-week-old male KK-Ay and C57Bl/6 mice were injected intraperitoneally with 300 or 600 mg/kg acetaminophen, and euthanized 6 h later. Liver histology was assessed, and hepatic expression of 4-hydroxy-2-nonenal was detected by immunohistochemistry. Levels of reduced glutathione were determined spectrophotometrically. Phosphorylation of c-Jun NH2-terminal kinase (JNK) was analyzed by Western blotting. Hepatocytes were isolated from both strains by collagenase perfusion, and cell death and oxidative stress were measured fluorometrically by use of propidium iodide and 5-(and-6)-chloromethyl-2'7'-dichloro-dihydrofluorescein diacetate acetyl ester, respectively....<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Pancreatic acinar-specific overexpression of Reg2 gene offered no protection against either experimental diabetes or pancreatitis in mice
Reg proteins are normally expressed in pancreatic acinar cells, and the level of several of these proteins was significantly induced upon damage to the endocrine or exocrine pancreas. It has been established that Reg1 and pancreatic islet neogenesis-associated protein [INGAP, Reg3] promote the growth or regeneration of the endocrine islet cells. Recent reports suggest that Reg2 is an autoantigen normally expressed in islet β-cells. Reg2 overexpression in vitro offered protection to insulinoma cells. Overexpressed Reg3 increased cyclin D1 and CDK4 levels and the rate of proliferation in insulinoma cells. Acinar-specific overexpression of INGAP increased β-cell mass and protected the animals from streptozotocin-induced diabetes. Moreover, Reg2 gene expression was induced during pan...
In Young Girls, Obesity Linked to Early Puberty, Analysis Reveals
Unanswered questions remain, including psychological impact, researcher says (Source: The Doctors Lounge - Health News)
In Young Girls, Obesity Linked to Early Puberty, Analysis Reveals
Unanswered questions remain, including psychological impact, researcher says (Source: The Doctors Lounge - Health News)
Wireless sensor watches blood sugar for diabetics
WASHINGTON (Reuters) - Researchers have developed an implantable sensor that measures blood sugar continuously and transmits the information without wires -- a milestone, they said, in diabetes treatment. (Source: Reuters: Health)
A Multiplex Immunoassay for Human Adipokine Profiling [Articles]
CONCLUSIONS:
Our findings underscore the relevance of the novel adipokines cathepsin S and chemerin, but foremost the potential of this novel method for both comprehensive adipokine profiling in large patient cohorts and for biological discovery. (Source: Clinical Chemistry)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Lipoprotein(a) and Risk of Type 2 Diabetes [Lipids, Lipoproteins, and Cardiovascular Risk Factors]
CONCLUSIONS:
Our results indicated that Lp(a) was associated inversely with risk of type 2 diabetes independently of risk factors, in contrast to prior findings of positive associations of Lp(a) with cardiovascular risk. (Source: Clinical Chemistry)
Implantable Sensor Measures Blood Sugar Levels
Wireless device transmitted accurate readings in pigs for more than a year, study shows (Source: The Doctors Lounge - Health News)
Free Diabetes Education and Support Groups in Florida
Ongoing diabetes education and support groups are offered for free in numerous locations. These groups are invaluable for anyone who is living with either type 1 or type 2 diabetes. These groups are particularly informative for anyone who has just recently been diagnosed and needs guidance on coping methods. Caregivers are encouraged to attend meetings with their loved ones. Guest speakers come and lecture on various topics.
Group 1: August 4th at 10 AM
Coral Springs Medical Center
3100 Coral Hills Dr., Conference Room A
read more (Source: Diabetes News from dLife.com)
Free Diabetes Education and Support Groups in Florida
Ongoing diabetes education and support groups are offered for free in numerous locations. These groups are invaluable for anyone who is living with either type 1 or type 2 diabetes. These groups are particularly informative for anyone who has just recently been diagnosed and needs guidance on coping methods. Caregivers are encouraged to attend meetings with their loved ones. Guest speakers come and lecture on various topics.
Group 1: August 4th at 10 AM
Coral Springs Medical Center
3100 Coral Hills Dr., Conference Room A
read more (Source: Diabetes News from dLife.com)
One Molecule, Many More Insulin-Producing Cells to Treat Diabetes, Says Pitt Team
July 28, 2010 (EurekAlert) - With a single stimulatory molecule, human insulin-producing beta cell replication can be sustained for at least four weeks in a mouse model of diabetes, according to researchers at the University of Pittsburgh School of Medicine in Diabetes, a journal of the American Diabetes Association.
read more (Source: Diabetes News from dLife.com)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
One Molecule, Many More Insulin-Producing Cells to Treat Diabetes, Says Pitt Team
July 28, 2010 (EurekAlert) - With a single stimulatory molecule, human insulin-producing beta cell replication can be sustained for at least four weeks in a mouse model of diabetes, according to researchers at the University of Pittsburgh School of Medicine in Diabetes, a journal of the American Diabetes Association.
read more (Source: Diabetes News from dLife.com)
South Africa: Gauteng Citizens Urged to Vaccinate Against H1N1
Gauteng Department of Health and Social development is urging pregnant women, patients with chronic lung and heart diseases, diabetic, school going learners under the age of 20 as well as senior citizens over 65 years to immunize against H1N1 virus by Friday, 31 July 2010. (Source: AllAfrica News: Health and Medicine)
New weight advice for pregnancy
Many newspapers have reported on new official guidelines for how women can manage their weight before, during and after pregnancy. The advice comes from the National Institute for Health and Clinical Excellence (NICE).
The importance of the guidelines are borne out by figures suggesting that more mothers than ever are overweight. The Guardian suggests that, ?15-20% of women getting pregnant are overweight or obese?. The Daily Mail puts the number higher, saying that ?almost half of expectant mothers are overweight or obese?. It goes on to spell out the dangers of being obese or overweight during pregnancy, which include ?fatal health conditions such as blood clots, pre-eclampsia, miscarriages and stillbirths?.
The newspapers also dispel the myth that women should eat for two du...
PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways
Peroxisome proliferator-activated receptors (PPAR α, β/δ and γ) play a key role in metabolic regulatory processes and gene regulation of cellular metabolism, particularly in the cardiovascular system. Moreover, PPARs have various extra metabolic roles, in circadian rhythms, inflammation and oxidative stress. In this review, we focus mainly on the effects of PPARs on some thermodynamic processes, which can behave either near equilibrium, or far-from-equilibrium. New functions of PPARs are reported in the arrhythmogenic right ventricular cardiomyopathy, a human genetic heart disease. It is now possible to link the genetic desmosomal abnormalitiy to the presence of fat in the right ventricle, partly due to an overexpression of PPARγ. Moreover, PPARs are...
The Role of Peroxisome Proliferator-Activated Receptor β/δ on the Inflammatory Basis of Metabolic Disease
The pathophysiology underlying several metabolic diseases, such as obesity, type 2 diabetes mellitus, and atherosclerosis, involves a state of chronic low-level inflammation. Evidence is now emerging that the nuclear receptor Peroxisome Proliferator-Activated Receptor (PPAR)β/δ ameliorates these pathologies partly through its anti-inflammatory effects. PPARβ/δ activation prevents the production of inflammatory cytokines by adipocytes, and it is involved in the acquisition of the anti-inflammatory phenotype of macrophages infiltrated in adipose tissue. Furthermore, PPARβ/δ ligands prevent fatty acid-induced inflammation in skeletal muscle cells, avoid the development of cardiac hypertrophy, and suppress macrophage-derived inflammation in atheroscler...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Reply
We appreciate the interest and comments about our article. Drs Tariq and Mitchell state that some literature on Stratus OCT report retinal thinning in diabetics with minimal or no diabetic retinopathy (DR)?in contrast to our article, which reported no thinning compared with controls. Drs Tariq and Mitchell also ask whether such discrepancy between studies may be accounted for by correcting for the effects of race, age, and sex on retinal thickness (as we did in our study). This is an excellent point and, in our opinion, a very important consideration when designing or interpreting studies with OCT-based outcomes. (Source: American Journal of Ophthalmology)
Media Type: Textbook Synopsis: It is rare for any book to be both informative and entertaining, much less a medical textbook. But, with a wealth of practical information conveyed in a jaunty, almost irreverent style, Dr. Jonathan Walker's Diabetic Retinopathy for the Comprehensive Ophthalmologist manages to be just that. (Source: American Journal of Ophthalmology)
Macular Thickness in Diabetic Subjects Without Retinopathy
The recent report by Kashani and associates analyzing retinal thickness by race, gender, and age adds to the growing literature on optical coherence tomography measured retinal parameters in different populations. Kashani and associates reported Stratus OCT measurements of macular parameters in white, black, and Hispanic individuals of both sexes, including those with diabetes but without retinopathy. They reported no significant differences in the macular parameters of individuals with diabetes without retinopathy compared with controls, using data adjusted for race, gender, and age group. They also reported that mean foveal thickness and foveal center point thickness were statistically greater in males than in females. Black persons had a significantly thinner mean foveal thickness and c...
Too much spent on diabetes drugs
Too much is being spent by the NHS on diabetes drugs, which take 7% of the UK prescribing budget, researchers have claimed (Source: Nursing in Practice)
No Effect of Selenium Supplementation on Serum Glucose Levels in Men with Prostate Cancer
Conclusion: These results do not support a relationship between selenium supplementation and changes in serum glucose levels. Recommendations about selenium supplementation and risk of diabetes will require more definitive studies. (Source: The American Journal of Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Not Your Otitis Media 101
A 58-year-old man with diabetes mellitus presented with a left earache and decreased hearing. Despite antibiotic treatment for otitis media, followed by treatment with another antibiotic and wick placement for refractory otitis media and newly diagnosed otitis externa, dizziness and headache developed. (Source: The American Journal of Medicine)
Health Insurance and Cardiovascular Disease Risk Factors
Conclusion: The treatment and control of hypertension and hypercholesterolemia are lower among uninsured adults. Increasing the proportion of insured individuals may be a means to improve the treatment and control of cardiovascular disease risk factors and to reduce health disparities. (Source: The American Journal of Medicine)
Depression and Incident Diabetic Foot Ulcers: A Prospective Cohort Study
Conclusion: Major depression by Patient Health Questionnaire-9 is associated with a 2-fold higher risk of incident diabetic foot ulcers. Future studies of this association should include better measures of peripheral neuropathy and peripheral arterial disease, which are possible confounders or mediators. (Source: The American Journal of Medicine)
Effects of Acute Psychological Stress on Glucose Metabolism and Subclinical Inflammation in Patients with Post-traumatic Stress Disorder
In conclusion, acute stress induces postprandial blood glucose peaks and elevated insulin levels and a selective decrease of systemic immune markers and the proinflammatory regulator of the NFκB cascade, which are associated with type 2 diabetes. This points towards an independent effect of acute psychological stress on glucose metabolism and inflammation.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Indomethacin Activates Peroxisome Proliferator-activated Receptor ? to Improve Insulin Resistance in Cotton Pellet Granuloma Model
Horm Metab ResDOI: 10.1055/s-0030-1261952AbstractInflammation is involved in the development of insulin resistance and diabetes. However, the effectiveness of anti-inflammatory drugs in diabetic therapy remains obscure. In the present study, the possible mechanisms of indomethacin, one of the nonsteroidal anti-inflammatory drugs, in the improvement of insulin resistance were investigated. Indomethacin treatment significantly decreased cotton pellet implantation induced white blood cell count elevation and immune cells infiltration in epididymal white adipose tissue. Also, cotton pellet implantation induced impaired glucose utilization and insulin resistance were improved by indomethacin. The decrement in phosphoinsulin receptor and phospho-Akt levels induced by cotton pellet implantation w...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Poorly controlled Type 2 diabetics have decreased lung function
Patients with Type 2 diabetes who have poor glycemic control have reduced pulmonary function compared with their well-controlled peers, suggest study findings. (Source: MedWire News - Diabetes)
Diabetes drugs' "spiralling costs"
As much as 7% of the entire NHS budget on medicines is being spent on diabetes drugs, researchers have said (Source: Pharmacy Europe)
Impact Of Childhood Obesity Goes Beyond Health
Adults who have been overweight since high school risk a lifetime of disease, discrimination and poverty. A new study of obese 40-year-olds found those who were overweight teens were three times more likely to suffer chronic health problems such as heart disease, diabetes and hypertension. They were also much more likely to be unemployed or receiving welfare.» E-Mail This » Add to Del.icio.us (Source: NPR Health and Science)
One molecule, many more insulin-producing cells to treat diabetes, says Pitt team
(University of Pittsburgh Schools of the Health Sciences) With a single stimulatory molecule, human insulin-producing beta cell replication can be sustained for at least four weeks in a mouse model of diabetes, according to researchers at the University of Pittsburgh School of Medicine in Diabetes. They also found several cocktails of molecules that drive human beta cells to replicate, as well as important differences between mouse and human beta cells that could influence how these approaches are best used to treat diabetes. (Source: EurekAlert! - Medicine and Health)
Implanted glucose sensor works for more than 1 year
(University of California - San Diego) Bioengineers at the University of California, San Diego and GlySens Incorporated have developed an implantable glucose sensor and wireless telemetry system that continuously monitors tissue glucose and transmits the information to an external receiver. The paper, published in the July 28, 2010 issue of the journal Science Translational Medicine, describes the use of this glucose-sensing device as an implant in animals for over one year. After human clinical trials and FDA approval, the device may be useful to people with diabetes as an alternative to finger sticking and short-term, needle-like glucose sensors that have to be replaced every three to seven days. (Source: EurekAlert! - Medicine and Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Weight-Management Web Site Helps Regular Users the Most
Spending a few minutes every month on a weight-management Web site is almost as effective as having a personal coach when it comes to avoiding weight rebound, according to a Kaiser Permanente study. Medscape Medical News (Source: Medscape Today Headlines)
Women with diabetes in pregnancy have increased arterial stiffness
Women who have gestational diabetes mellitus or Type 2 diabetes in pregnancy have increased arterial stiffness compared with nondiabetic pregnant women, say researchers. (Source: MedWire News - Diabetes)
Alcohol may fight rheumatoid arthritis
Moderate drinking has been linked to a variety of health benefits, including a reduced risk of heart disease, stroke, and diabetes. According to a new study, drinking alcohol may also ease the pain of -- and lower the risk of developing -- rheumatoid arthritis, a potentially crippling autoimmune disorder. (Source: CNN.com - Health)
The evolving burden of HIV infection compared with other chronic diseases in northern Italy*
The aim of the study was to estimate the burden and direct costs of diseases in HIV-infected patients (either opportunistic illnesses or other chronic diseases) with respect to the HIV-uninfected population. These estimates will be useful for the projection of future direct costs of HIV care. A population-based study was conducted in the Brescia Local Health Agency in northern Italy. An administrative database recorded diagnoses, deaths, drug prescriptions and health resource utilization for all medical and surgical patients in the region from 2003 to 2007. The study estimated the prevalence of HIV infection as well as HIV-related mortality and annual cost per patient, and compared mortality and costs related to HIV infection with those for a set of 15 other chronic diseases. The standardi...
Vascular protection in diabetic stroke: role of matrix metalloprotease-dependent vascular remodeling
Authors: Mostafa M Elgebaly, Roshini Prakash, Weiguo Li, Safia Ogbi, Maribeth H Johnson, Erin M Mezzetti, Susan C Fagan
& Adviye Ergul (Source: Journal of Cerebral Blood Flow)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Magnesium intake and type II diabetes in Japanese men and women: the Japan Public Health Center-based Prospective Study
Authors: A Nanri, T Mizoue, M Noda, Y Takahashi, K Kirii, M Inoue
& S Tsugane (Source: European Journal of Clinical Nutrition)
Insulin-requiring diabetes in Ethiopia: associations with poverty, early undernutrition and anthropometric disproportion
Authors: S Fekadu, M Yigzaw, S Alemu, A Dessie, H Fieldhouse, T Girma, E R Trimble, D I W Phillips
& E H O Parry (Source: European Journal of Clinical Nutrition)
Insulin modulates cytokine release and selectin expression in the early phase of allergic airway inflammation in diabetic rats
Conclusion: Data presented suggest that insulin modulates the production/release of TNF-alpha and IL-1beta, the expression of P- and E-selectin, and the associated neutrophil migration into the lungs during the early phase of the allergic inflammatory reaction. (Source: BMC Pulmonary Medicine - Latest articles)
Cardiovascular drugs are most commonly prescribed pills
Four of the five top prescribed drugs are for heart diseaseRelated items from OnMedicaPoor patients more likely to die after heart surgery than richNew catheter technique doubles survival after heart attackBlood sugar control in diabetics to cut heart riskAll over-55s should take blood pressure pillsPlan to switch to angioplasty for first-line heart treatment (Source: OnMedica Latest News)
Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus
Conclusion:
The present study provides evidence that MCF2L2, ADIPOQ and SOX2 genetic polymorphisms have effects on the resistance of DN in female T1D patients, and suggests that the linkage with DN in chromosome 3q may be explained by the cumulated genetic effects. (Source: BMC Medical Genetics - Latest articles)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Transition of kidney tubule cells to a senescent phenotype in early experimental diabetes
Diabetic nephropathy is the commonest cause of end-stage renal disease. Inordinate kidney growth and glomerular hyperfiltration at the very early stages of diabetes are putative antecedents to this disease. The kidney is the only organ that grows larger with the onset of diabetes mellitus, yet there remains confusion about the mechanism and significance of this growth. Here we show that kidney proximal tubule cells in culture transition to senescence in response to oxidative stress. We further determine the temporal expression of G1 phase cell cycle components in rat kidney cortex at days 4 and 10 of streptozotocin diabetes to evaluate changes in this growth response. In diabetic rats we observe increases in kidney weight-to-body weight ratios correlating with increases in expression of th...
Experimental obesity drug avoids brain effects that troubled predecessors
A second-generation experimental anti-obesity and diabetes drug has shown promise in reducing body weight in rodents just as effectively as the predecessor rimonabant while avoiding the risk of psychiatric side effects that led to the withdrawal of rimonabant from the market and stopped further development of other brain-penetrating drugs of its type. (Source: ScienceDaily Headlines)
Risk of Acute Myocardial Infarction, Stroke, Heart Failure, and Death in Elderly Medicare Patients Treated With Rosiglitazone or Pioglitazone [Original Contribution]
Conclusion Compared with prescription of pioglitazone, prescription of rosiglitazone was associated with an increased risk of stroke, heart failure, and all-cause mortality and an increased risk of the composite of AMI, stroke, heart failure, or all-cause mortality in patients 65 years or older. (Source: JAMA)
Rosiglitazone and the Case for Safety Over Certainty [Editorial]
(Source: JAMA)
Adding Noninsulin Antidiabetic Drugs to Metformin Therapy for Type 2 Diabetes [Letters]
(Source: JAMA)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Adding Noninsulin Antidiabetic Drugs to Metformin Therapy for Type 2 Diabetes [Letters]
(Source: JAMA)
Adding Noninsulin Antidiabetic Drugs to Metformin Therapy for Type 2 Diabetes--Reply [Letters]
(Source: JAMA)
HbA1c Alone a Weak Predictor of Diabetes and Cardiovascular Risk
Don't rely on hemoglobin (Hb)A1c alone to identify patients at risk for diabetes and heart disease. It's far less precise than glucose tolerance or fasting plasma glucose tests, two new studies show. Reuters Health Information (Source: Medscape Medical News Headlines)
Arguments continue over the metabolic syndrome
The metabolic syndrome has been the subject of controversy for many years: to this day, agreement cannot be reached between the diabetes and cardiology communities about the validity of naming and...
For complete story visit theheart.org. (Source: theHeart.org)
Ben-Gurion University of the Negev Researchers Identify Risks of Hypertension in Young Adults
July 27, 2010 (EurekAlert) - Ben-Gurion University of the Negev (BGU) researchers reveal in a new, large-scale study that "normal" blood pressure at age 17 can still predict hypertension at early adulthood and that teenage boys are three to four times more likely to develop high blood pressure in early adulthood than girls.
read more (Source: Diabetes News from dLife.com)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Ben-Gurion University of the Negev Researchers Identify Risks of Hypertension in Young Adults
July 27, 2010 (EurekAlert) - Ben-Gurion University of the Negev (BGU) researchers reveal in a new, large-scale study that "normal" blood pressure at age 17 can still predict hypertension at early adulthood and that teenage boys are three to four times more likely to develop high blood pressure in early adulthood than girls.
read more (Source: Diabetes News from dLife.com)
Cranberry
This fact sheet provides basic information about cranberry—common names, uses, potential side effects, and resources for more information. Cranberries are the fruit of a native plant of North America. These red berries are used in foods and in herbal products.What Cranberry Is Used ForHistorically, cranberry fruits and leaves were used for a variety of problems, such as wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.Recently, cranberry products have been used in the hope of preventing or treating urinary tract infections or Helicobacter pylori (H. Pylori) infections that can lead to stomach ulcers, or to prevent dental plaque. Cranberry has also been reported to have antioxidant and anticancer activity. (Source: NCCAM Featured Content)
New Obesity Compound Shows Promise in Mice
A compound similar to the once-promising weight loss drug Acomplia (rimonabant) helped obese mice lose weight and lower their blood lipids and blood sugar without psychological side effects, U.S. researchers said on Monday. Reuters Health Information (Source: Medscape Today Headlines)
If You?re Laughing, You?re Living?Longer
Dear Health Conscious Reader,
Do you want to hear the funniest joke in the world?
If you do searches for the ?funniest joke in the world,? this is the most common winner for U.S. audiences?
A couple of hunters are out in the woods when one of them grabs his chest, falls to the ground, and then lies there motionless.
The other hunter calls 911. ?My friend won?t get up, and I think he?s dead! What should I do??
The operator, in a calm, soothing voice, says: ?Just take it easy. I can help. First, you have to make sure he?s dead.?
There?s a silence? then the operator hears two shots.
The hunter?s voice comes back on the line. ?Okay, what do I do next??
Now? I know jokes that I think are a lot funnier, but they?re a little too risqué to put in your letter. But...
Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance [Medical_Sciences]
Obesity and metabolic syndrome result from excess calorie intake and genetic predisposition and are mechanistically linked to type II diabetes... (Source: Proceedings of the National Academy of Sciences)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic {beta}-like cells [Medical_Sciences]
Diabetes mellitus is characterized by either the inability to produce insulin (type 1 diabetes) or as insensitivity to insulin secreted... (Source: Proceedings of the National Academy of Sciences)
Supramolecular insulin assembly II for a sustained treatment of type 1 diabetes mellitus [Applied_Biological_Sciences]
In this study,... (Source: Proceedings of the National Academy of Sciences)
FDA Alert - Vialipro Dietary Supplement Recalled: Undeclared Drug Ingredient
The undeclared ingredient may pose a threat to the consumer because the interaction of the analogue with some prescription drugs (such as nitroglycerin) may lower blood pressure to dangerous levels. Consumers with diabetes, high blood pressure, high cholesterol, or heart disease often take other prescription drugs. (Source: NCCAM Featured Content)
The More Frequently You Log On, The More Weight You Can Keep Off
July 27, 2010 (EurekAlert) - The more people used an interactive weight management website, the more weight loss they maintained, according to a Kaiser Permanente Center for Health Research study published online today in the open access Journal of Medical Internet Research.
read more (Source: Diabetes News from dLife.com)
The More Frequently You Log On, The More Weight You Can Keep Off
July 27, 2010 (EurekAlert) - The more people used an interactive weight management website, the more weight loss they maintained, according to a Kaiser Permanente Center for Health Research study published online today in the open access Journal of Medical Internet Research.
read more (Source: Diabetes News from dLife.com)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Heart news digest
Danger of food firms paying for obesity campaign, diabetes timebomb and bogus collectors are in the news today (Source: BHF National News)
Staff Nurse, Endocrinology - Nottingham University Hospitals NHS Trust
Added via www.healthjobsuk.com
Nottingham University Hospitals NHS Trust are seeking a dynamic and motivated registered nurse with a desire to develop leadership skills to join the team at their newly refurbished Acute Medical Ward. The Ward has a special interest in the treatment of diabetic patients.
Successful candidates will gain experience in endocrinology as a speciality as well as experience in looking after patients with general medical disorders.
The deadline for applications is 9 August 2010. For more information please follow the link below.
Further details (Source: Society for Endocrinology)
At-Home Monitoring Crucial For Managing Diabetes In Pets
Monitoring the blood glucose levels of diabetic pets can eliminate the life-threatening risks of low blood sugar and minimize the complications of diabetes, such as cataracts, recurring infections and pancreatitis, says veterinarian Dr. Sara Ford. Dr. Ford will be speaking on the subject of diabetes management and at-home blood glucose monitoring for diabetic pets at the 2010 American Veterinary Medical Association (AVMA) Convention on Saturday, July 31, in Atlanta. "If you're a human diabetic you monitor your blood sugar between 4-6 times a day," says Dr. Ford... (Source: Health News from Medical News Today)
The physical health challenges in patients with severe mental illness: cardiovascular and metabolic risks
This supplement is the output of a roundtable discussion, attended by a multidisciplinary panel with a broad range of expertise, which includes the treatment of severe mental illness, cardiovascular disease, diabetes and pharmaceutical prescribing.
The roundtable and writing of the supplement were organised and paid for by MSD, including the payment of Steve Titmarsh, a medical writer who was involved in the preparation and editing of this document (Source: Journal of Psychopharmacology)
Laparoscopic versus open cholecystectomy in diabetic patients and postoperative outcome
Conclusions When feasible, LC was a safe procedure in diabetes. Open surgery with comorbidities increased the operative risks. Our study
was not randomized, and therefore selection bias to type of procedure may affect the results.
Content Type Journal ArticleDOI 10.1007/s00464-010-1248-yAuthors
Hannu Paajanen, Kuopio University Hospital Department of Surgery Kuopio FinlandSatu Suuronen, Mikkeli Central Hospital Department of Surgery Mikkeli FinlandPia Nordstrom, Mikkeli Central Hospital Department of Surgery Mikkeli FinlandPekka Miettinen, Kuopio University Hospital Department of Surgery Kuopio FinlandLeo Niskanen, Kuopio University Hospital Department of Medicine Kuopio Finland
Journal Surgical EndoscopyOnline ISSN 1432-2218Print ISSN 0930-2794 (Source: Surgi...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Calibra Gains FDA Clearance To Market Finesse? Insulin Patch-Pen For Three-Day Use With Novolog®
Calibra Medical announced it received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to market its Finesse? insulin patch-pen for up to three-day use with Novo Nordisk's Novolog® rapid acting insulin. Combining the mealtime therapy-adherence benefits of insulin pumps with the simplicity and affordability of syringes and pens, Calibra's novel bolus-only patch-pen is a small, adhesively attached, flat device that can be operated discretely through clothing to deliver mealtime, snack time, and correction bolus insulin in seconds... (Source: Health News from Medical News Today)
Reducing The Health Risks Of Obesity Without Serious Side Effects
The drug rimonabant was developed as a treatment for obesity and its myriad of serious health consequences (for example, type 2 diabetes). Despite having its desired effects on weight, which it decreased, and on levels of glucose and fats in the blood, rimonabant was never approved for use in the US because of serious neurological side effects including depression and anxiety... (Source: Health News from Medical News Today)
First Nations People On Peritoneal Dialysis At Greater Risk Of Infection And Death
First Nations people in Canada on peritoneal dialysis are at increased risk of peritonitis and death, irrespective of whether they live in a rural or urban location, found a study published in CMAJ (Canadian Medical Association Journal). The high prevalence of diabetes, obesity and hypertension in Canada's First Nations, or aboriginal, population is fuelling the rapid growth of kidney disease and renal failure and consequent need for care and dialysis. Peritonitis is inflammation of the peritoneum (the inner lining of the abdominal and pelvic walls), often caused by infection... (Source: Health News from Medical News Today)
Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes?
A growing body of evidence supports an important role for the endocannabinoid system as a regulator of appetite, body weight, and systemic metabolism, which is overactive in obesity and type 2 diabetes. While initial attempts to target this system using the cannabinoid receptor inverse agonist rimonabant were successful in producing modest weight loss and improving obesity-related metabolic complications in humans, adverse central nervous system side effects precluded introduction of this drug into clinical practice. However, new data, presented by Tam and colleagues in this issue of the JCI, demonstrate that selective blockade of peripheral cannabinoid receptors may be a novel successful therapeutic approach. (Source: Journal of Clinical Investigation)
Scientists discover olive oil directly impacts genes to halt inflammation
(NaturalNews) Research has been steadily accumulating that olive oil, a main component of the Mediterranean diet, has extensive health-protective properties. For example, phytonutrient components of olive oil have been found to be effective against breast cancer cells (http://www.naturalnews.com/025633_cancer_olive_oil_brst.html) and studies suggest the abundance of olive oil in the Mediterranean style of eating may be the reason that diet helps prevent depression (http://www.naturalnews.com/027265_depression_mediterranean_diet_health.html). Now scientists have discovered that phenolic compounds in olive oil directly repress genes linked to inflammation. This could be especially important in halting the dangerous effects of metabolic syndrome. Characterized by excess abdominal fat, high ch...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Early Puberty Tied To Obesity In Girls
A review of more than 100 studies found overweight girls tend to reach puberty earlier than their peers do. While some researchers have argued hitting puberty early in life makes a person at higher risk for metabolic syndrome and diabetes, Emily Walvoord, M.D., pediatric endocrinologist and review author, found such diseases are not linked to early puberty, but obesity. The review appears online in the Journal of Adolescent Health. "Early puberty is one of the many outcomes of obesity," said Walvoord, a professor at the Indiana University School of Medicine... (Source: Health News from Medical News Today)
ALR Technologies Announces FDA 510(k) Filing For Health-e-Connect (HeC) System -- Health Care For Diabetes Patients
ALR Technologies Inc. (OTCBB: ALRT) announces that on July 23, 2010 the Company submitted a 510(k) application to the FDA for its proprietary Health-e-Connect (HeC) System. The HeC system is an internet-based product intended for diabetic patients and their health care providers to improve communication and monitoring of patients' health management programs. One aspect of the system is that HeC will incorporate data uploaded from patients' glucometers into the ALRT database to quickly assess user compliance and performance compared to provider set targets... (Source: Health News from Medical News Today)
iCo Therapeutics Inc. Receives Health Canada Clearance To Conduct Phase II DME Trial With iCo-007
iCo Therapeutics Inc. (TSX VENTURE:ICO) is pleased to announce that the Therapeutic Products Directorate, a division of Health Canada, has issued a No Objection Letter response to the Company regarding its iCo-007 Phase II Diabetic Macular Edema (DME) Clinical Trial Application (CTA). "Based on our successful submission iCo may now proceed into a Phase II clinical trial for this indication in Canada, marking an enormous milestone for the company," stated Dr. Peter Hnik, iCo's Chief Medical Officer... (Source: Health News from Medical News Today)
Fetal exposure to severe Chinese famine increases risk for hyperglycemia
Study results suggest that fetal- and late-childhood exposure to the severe Chinese famine of 1959?1961 is associated with significantly increased risk for hyperglycemia or Type 2 diabetes in later life. (Source: MedWire News - Diabetes)
Editorial Board
(Source: Diabetes Research and Clinical Practice)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Contents
(Source: Diabetes Research and Clinical Practice)
Monitoring diabetes in patients and pets
COLUMBIA, Mo., July 26 (UPI) -- U.S. researchers say a diabetes monitoring device reduces the stress of obtaining multiple blood samples from patients -- whether human or animal.
Health - Diabetes mellitus - Conditions and Diseases - Endocrine Disorders - Pancreas (Source: Health News - UPI.com)
Are you a diabetes timebomb? If you're slightly overweight, you could be one of a million Britons with undiagnosed diabetes
A little tubbier than you'd prefer? Like a million other Britons, you could be suffering from undiagnosed diabetes, putting you at high risk of impotence, heart problems and even losing a limb... (Source: the Mail online | Health)
Short sleep duration may increase impaired fasting glucose risk
People who sleep for less than 6 hours per night have a three-fold increased risk for developing impaired fasting glucose compared with those who sleep for 6 to 8 hours per night, a US study suggests. (Source: MedWire News - Diabetes)
Think before you snack: Auto-eating is part of the new obesity epidemic
WITH one in four adults in the UK now dangerously overweight obesity has become a modern day plague that threatens to cause an explosion in deaths from diabetes and heart disease. Yet are diets really the solution or could we tackle our expanding waistlines more effectively by making small changes to our eating habits? (Source: Daily Express - Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Low flow oxygenation of full-excisional skin wounds on diabetic mice improves wound healing by accelerating wound closure and reepithelialization
Oxygen-based therapies have proven effective in treating chronic and difficult-to-heal skin wounds, but the current therapeutic approaches suffer from major limitations and they do not allow for continuous wound treatment. Here we examined whether the continuous treatment of wounds with pure oxygen at low flow rates accelerates wound closure and improves wound healing in a murine model of diabetic skin wounds. Two full-excisional dorsal skin wounds were generated on 15-week-old diabetic db/db mice and treated for 10 weeks continuously with pure oxygen (>99·9%) at low flow rates (3 ml/h). After 6 days, oxygen treatment resulted in a mean reduction of the original wound size by 60·2% as compared with only 45·2% in wounds on control mice that did not receive pure oxygen.(P = 0·022). After...
Protocol for a national audit on self-reported confidence levels, training requirements and current practice among trainee doctors in the UK: The Trainees Own Perception of Delivery of Care in Diabetes (TOPDOC) Study
DiscussionIt is anticipated that the results of this national study will clarify confidence levels and current practice among trainee doctors in the provision of care for people with diabetes. The responses will inform efforts to enhance postgraduate training in diabetes, potentially improving the quality of care for people with diabetes. (Source: BMC Medical Education)
Magnets applied to acupuncture points as therapy: a literature review
Source: DARE
Area: Evidence > Complementary Medicine
CRD Summary: The review concluded that further investigation of acu-magnet therapy was warranted, particularly for the management of diabetes and insomnia, however, the quality of the trials prevented treatment recommendations. Despite limitations in the review, the authors cautious conclusions are likely to be reliable.
CRD Commentary: The review question was supported by clear if broad inclusion criteria. Several databases were searched. The search was restricted by language (English and Chinese) and the authors did not systematically attempt to locate unpublished papers, thus increasing the likelihood of language and publication biases. Risk of publication bias was acknowledged by the authors. Although six reviewers performed the d...
CAS and MHRA statements on cardiovascular risks associated with rosiglitazone
Source: MHRA, CAS
Area: News
Following recent reports of the increased cardiovascular risk associated with the use of rosiglitazone, the Central Alerting System and the MHRA have issued a "Dear Doctor" letter outlining current advice and information about the use of rosiglitazone (Avandia®, Avandamet®?) in the treatment of diabetes.
The letter states that a Europe-wide review of available data on the risks and benefits of rosiglitazone by the European Committee on Medicinal Products for Human Use (CHMP) is anticipated to be completed by September 2010, but in the meantime healthcare professionals should closely observe the current Contra-indications, warnings and precautions and monitoring requirements, and consider alternative treatments where appropriate.
Additio...
Recommended management of type 1 diabetes with insulin
Insulin therapy in type 1 diabetes aims to achieve optimal blood glucose control while avoiding troublesome hypoglycaemia. Our Drug review discusses the properties of currently available insulins, followed by sources of further information and a review of prescription data. Copyright © 2010 Wiley Interface Ltd (Source: Prescriber)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Ezetimibe/simvastatin vs simvastatin in coronary heart disease patients with or without diabetes
Background:
Treatment guidelines recommend LDL-C as the primary target of therapy in patients with hypercholesterolemia. Moreover, combination therapies with lipid-lowering drugs that have different mechanisms of action are recommended when it is not possible to attain LDL-C targets with statin monotherapy. Understanding which treatment or patient-related factors are associated with attaining a target may be clinically relevant.
Methods:
Data were pooled from two multicenter, randomized, double-blind studies. After stabilization on simvastatin 20 mg, patients with coronary heart disease (CHD) alone and/or type 2 diabetes mellitus (T2DM) were randomized to ezetimibe 10 mg/simvastatin 20 mg (EZ/Simva) or simvastatin 40 mg. The change from baseline in low-density lipoprotein cholesterol (LDL-...
Addition of Soluble Soybean Polysaccharides to Dairy Products as a Source of Dietary Fiber
Increasing consumption of dietary fiber in food leads to many important health benefits: for example, reduction in blood cholesterol, reduced risk of diabetes, and improved laxation. Water soluble soybean polysaccharide (SSPS) is a dietary fiber extracted and refined from okara, a byproduct of soy manufacturing. It was incorporated into 3 categories of dairy-based products, thickened milkshake-style beverages, puddings, and low-fat ice cream, to the maximum amount without over-texturing the food. Rheological measurements and sensory tests were used to develop desirable SSPS-fortified products. From the rheological data, 4% SSPS-fortified dairy beverages and 4% SSPS -fortified puddings were in the range of commercial products. From sensory analyses, 4% SSPS-fortified dairy beverage with 0.0...
The Role of Kidney-Pancreas Transplantation in Diabetic Kidney Disease
Abstract For patients with type 1 diabetes, innovations in insulin formulations and delivery have improved the ability to achieve excellent
blood glucose control. However, it is uncommon to achieve euglycemia, particularly while avoiding complications arising from
hypoglycemia. Pancreas transplantation remains the only broadly applied treatment strategy that can result in normalization
of blood glucose, but this must be weighed against the risks of a surgical procedure and subsequent immunosuppression. To
improve this risk/benefit ratio, pancreas transplantation is typically performed in patients with kidney failure who are to
undergo kidney transplantation and immunosuppression (simultaneous pancreas-kidney transplant) or who have undergone kidney
transplant and are oblig...
Rosiglitazone Revisited: An Updated Meta-analysis of Risk for Myocardial Infarction and Cardiovascular Mortality [Review Article]
Conclusions Eleven years after the introduction of rosiglitazone, the totality of randomized clinical trials continue to demonstrate increased risk for MI although not for CV or all-cause mortality. The current findings suggest an unfavorable benefit to risk ratio for rosiglitazone. (Source: Archives of Internal Medicine)
Lifestyle and Adiponectin Level: Four-Year Follow-up of Controlled Trials [Research Letters]
(Source: Archives of Internal Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Obese Kids' Feet Are Flatter and Fatter
Obese children tend to have flatter feet than their normal-weight peers, but it has been unclear whether that reflects a potential problem in the foot's bone structure or simply extra fat padding. A new study suggests that it's both. Reuters Health Information (Source: Medscape Diabetes Headlines)
Consumer Gene Test Results Misleading: U.S. Probe
People who send off their saliva to genetic testing companies to find out their risk for prostate cancer or diabetes are likely to get different results depending on the company they choose, government investigators told lawmakers on Thursday. Reuters Health Information (Source: Medscape Pathology Headlines)
Can Frozen Desserts be part of a Diabetes Meal Plan?
Are you worried that you can't have ice cream, popsicles or other frozen desserts as part of your diabetes meal plan? You are not alone - this can be a challenge for many people who have diabetes. It is possible for people with diabetes to incorporate frozen desserts into a balanced diabetes meal plan. Click to read now (Source: HealthCastle.com Nutrition Tips - written by Registered Dietitians)
AmMed Direct names new CEO
Nashville-based AmMed Direct, whose chief executive left the company in February amid an internal audit of the company?s Medicare billing practices, has named new leadership for the diabetes testing supply company. (Source: bizjournals.com Health Care:Health Insurance headlines)
AmMed Direct names new CEO
Nashville-based AmMed Direct, whose chief executive left the company in February amid an internal audit of the company?s Medicare billing practices, has named new leadership for the diabetes testing supply company. (Source: bizjournals.com Health Care:Biotechnology headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Skeleton Key: Bone Cells May Play a Part in Regulating the Body's Metabolism
Insulin , the well-known blood sugar hormone, may have a newly discovered function in the body that will rattle your bones--regulating skeletal growth and breakdown.Two new studies published online July 22 in Cell show that insulin stimulates both bone building and breakdown in mice through the hormone's effects on two types of bone cells: bone-building osteoblasts and bone-resorbing osteoclasts. What's more, these cells are involved in an intricate hormonal loop that in turn regulates not only insulin production, but also blood sugar levels and energy metabolism. The studies suggest that the skeleton may be an important regulator of whole-body energy metabolism, joining the ranks of known metabolic regulators such as muscle and fat. The authors conclude that their findings have important...
Fresh Air For Avandia
Drug Discovery: New diabetes drug insights may revive research efforts. (Source: Chemical and Engineering News)
Muscle gene may provide new treatments for obesity and diabetes
In muscle, a protein called MED1 normally suppresses a genetic program that holds in check certain energy expenditure pathways. But when Rockefeller University scientists removed this gene in mice, a number of genes that are usually suppressed were activated, suggesting that targeting the Med1 gene could provide new therapeutical approaches to treating such metabolic diseases as obesity and diabetes. (Source: The Rockefeller University Newswire)
Doctors Don?t ?Get? Their Patients
read more (Source: Diabetes News from dLife.com)
Doctors Don?t ?Get? Their Patients
read more (Source: Diabetes News from dLife.com)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Early Puberty Tied to Obesity in Girls
July 26, 2010 (Newswise) - A review of more than 100 studies found overweight girls tend to reach puberty earlier than their peers do.
While some researchers have argued hitting puberty early in life makes a person at higher risk for metabolic syndrome and diabetes, Emily Walvoord, M.D., pediatric endocrinologist and review author, found such diseases are not linked to early puberty, but obesity.
read more (Source: Diabetes News from dLife.com)
Early Puberty Tied to Obesity in Girls
July 26, 2010 (Newswise) - A review of more than 100 studies found overweight girls tend to reach puberty earlier than their peers do.
While some researchers have argued hitting puberty early in life makes a person at higher risk for metabolic syndrome and diabetes, Emily Walvoord, M.D., pediatric endocrinologist and review author, found such diseases are not linked to early puberty, but obesity.
read more (Source: Diabetes News from dLife.com)
Diabetes costs 'out of control' (BBC News Online, 26 July 2010)
Researchers from Cardiff University have suggested that a large rise in spending on drugs to control blood sugar is not fully explained by a rise in the number of people with type 2 diabetes, but is also due to a rise in the use of more expensive diabetes therapies.
Full article (Source: Society for Endocrinology)
Lecturer/Tutor Diabetes Nursing - King's College London
Added via www.jobs.ac.uk
The Florence Nightingale School of Nursing and Midwifery at King's College London are looking to recruit a well qualified nurse with specialist experience in diabetes nursing to become a Lecturer/Tutor in Diabetes Nursing. The successful applicant will work closely with Professor Angus Forbes (FEND Professor of Diabetes Nursing) to develop the School and partner Trusts as a centre for diabetes related nursing research and teaching.
Applicants for a Lectureship must hold a doctoral degree or be close to submitting their thesis and ideally be research active. Experienced nurses who hold a Bachelor's or Master's degree in Nursing or a related subject will also be considered for the role of Tutor.
The deadline for applications is 6 August 2010. For more information ...
Rare And Common Genetic Variations Responsible For High Triglyceride Levels In Blood
It can make blood look like cream of tomato soup. Patients with high levels of triglycerides in their blood, a disease called hypertriglyceridemia (HTG) face an increased risk for heart disease and stroke. HTG affects one in 20 people in North America and is also associated with obesity, diabetes and pancreatitis. Most people now understand the importance of LDL, the bad cholesterol and HDL, the good cholesterol, to their overall health. But high triglycerides are like the Rodney Dangerfield of the lipid world: they get less respect and notoriety compared to their cholesterol cousins... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Bone Plays Key Role In Insulin Regulation
New US research on mice suggests that bone plays a key role in insulin regulation and helps cells of the body take up glucose; as both these processes are impaired in people with type 2 diabetes the researchers suggest this discovery could lead to new diabetes drugs. Dr Gerard Karsenty from Columbia University Medical Center, New York, and colleagues found that the process of bone resorption, when old bone breaks down to make way for new growth, releases a hormone called osteocalcin that turns on insulin production and also helps cells take up glucose... (Source: Health News from Medical News Today)
Great Tastes And International Recipes That Reduce The Risk Of Heart Disease
The European Society of Cardiology (ESC) has announced the upcoming launch of its all-new European Cook Book. Bringing together recipes created by leading cardiologists from across its membership, the aim of this high quality book is to demonstrate that a diverse, heart-friendly diet can be achieved without compromising on taste. The ESC strongly endorses a healthy and balanced diet as an effective means of lowering the risks from conditions such as hypertension, diabetes and coronary artery disease... (Source: Health News from Medical News Today)
Ohio Sets Up High Risk Pool; Four Drug Companies Come Under Scrutiny For Payments To Pittsburgh Doctors, Nurses
The Associated Press/Bloomberg BusinessWeek: "Ohioans with pre-existing health conditions, such as cancer or diabetes, can apply for coverage under a new high-risk insurance pool beginning Aug. 1." Qualifications include evidence of a pre-existing condition, proof of Ohio residency and U.S... (Source: Health News from Medical News Today)
Man And Man's Best Friend Benefit From Diabetes Monitoring Device
The treatment of diabetes was revolutionized in 1922 when insulin was isolated from dogs. Since then, significant advances in human medicine have made diabetes more manageable for patients. Now, human medicine has returned the favor and used these advances to help dogs with diabetes. A University of Missouri researcher is using a continuous glucose monitoring device - commonly used in humans with diabetes - to help treat dogs and other animals. The device, which provides a detailed glucose picture of an animal over several days, will help pet owners manage their pets' diabetes... (Source: Health News from Medical News Today)
As Weight Goes Up, So Do Heart Risks
Title: As Weight Goes Up, So Do Heart RisksCategory: Health NewsCreated: 7/23/2010 12:10:00 PMLast Editorial Review: 7/26/2010 (Source: MedicineNet Diabetes General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Shedding Pounds Saved One Woman's Life
Title: Shedding Pounds Saved One Woman's LifeCategory: Health NewsCreated: 7/23/2010 12:10:00 PMLast Editorial Review: 7/26/2010 (Source: MedicineNet Diabetes General)
Avandia's future murky after FDA panel vote
The type 2 diabetes drug, already under a black-box warning, is examined again as more questions about its safety are raised. (Source: American Medical News - PROFESSION)
Diabetes costs 'out of control'
The NHS is spending too much on drugs for diabetes, say researchers who found the costs of medicines to control blood sugar have spiralled in recent years. (Source: BBC News | Health | UK Edition)
Diabetes risk factor for swine flu hospitalization
Results from an influenza surveillance project in Canada show that patients with diabetes who become infected with the pandemic influenza A virus are at significantly greater risk for hospitalization and intensive care unit admission than those without diabetes. (Source: MedWire News - Respiratory)
Maternal family history of diabetes lowers CVD risk in diabetic women
Australian researchers suggest that a maternal family history of diabetes may reduce the risk for cardiovascular disease in female, but not male, patients with diabetes. (Source: MedWire News - Diabetes)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Low BMI associated with increased mortality in diabetes
Read the full story on MD Consult:
Low BMI associated with increased mortality in diabetes (Source: MD Consult: News: Top Stories)
Effect of call-based counseling ringing true
The therapist-patient relationship is crucial to people battling depression, addiction, weight gain and diabetes. But that relationship might not always have to be in person to be effective.
Over the last decade, numerous hospitals and clinics have begun... (Source: OrlandoSentinel: Medical Research)
Effect of Call-Based Counseling Ringing True
The therapist-patient relationship is crucial to people battling depression, addiction, weight gain and diabetes. But that relationship might not always have to be in person to be effective.
Over the last decade, numerous hospitals and clinics have begun... (Source: OrlandoSentinel: Medical Research)
Prediabetes and prehypertension in disease free obese adults correlate with an exacerbated systemic proinflammatory milieu
Background:
Obesity is a pro-inflammatory state frequently associated with widespread metabolic alterations that include insulin resistance and deregulation of blood pressure (BP). This cascade of events in some measure explains the susceptibility of obese adults for co-morbid conditions like diabetes mellitus and hypertension.Hypothesis: We hypothesized that an elevated systemic proinflammatory burden correlates with dysglycemia and deregulated blood pressure.
Methods:
We analyzed the screening anthropometric and laboratory measures from healthy disease free obese adults (n=35; women (W) 27, men (M) 8) in a weight loss study.
Results:
Healthy obese normoglycemic (fasting serum glucose: FSG (Source: Journal of Inflammation)
Medical Treatment of Retinopathy of Type-2 Diabetes
Ophthalmologica 2004;218:291–296 (DOI:10.1159/000079469) (Source: Ophthalmologica)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Inadequate glucose control in type 2 diabetes is associated with impaired lung function and systemic inflammation: a cross-sectional study
Background:
Inadequate glucose control may be simultaneously associated with inflammation and decreased lung function in type 2 diabetes. We evaluated if lung function is worse in patients with inadequate glucose control, and if inflammatory markers are simultaneously increased in these subjects. Methods: Subjects were selected at the Colombian Diabetes Association Center in Bogota. Pulmonary function tests were performed and mean residual values were obtained for forced expiratory volume (FEV1), forced vital capacity (FVC) and FEV1/FVC, with predicted values based on those derived by Hankinson et al. for Mexican-Americans. Multiple least-squares regression was used to adjust for differences in known determinants of lung function. We measured blood levels of glycosylated hemoglobin (HBA1c...
Correlates of Echocardiographic Indices of Cardiac Remodeling Over the Adult Life Course. Longitudinal Observations From the Framingham Heart Study.
Conclusions-Cardiac remodeling over the adult life course is characterized by a distinct pattern of increasing LV wall thickness, decreasing LV dimensions, and increasing fractional shortening with advancing age. Overall, female sex, greater blood pressure load, and presence of diabetes mellitus serve to attenuate this remodeling pattern. These observations suggest a mechanism for the preponderance of women with hypertension and individuals with diabetes among patients with diastolic heart failure.
PMID: 20660804 [PubMed - as supplied by publisher] (Source: Circulation)
Angiotensin-I Converting Enzyme type 2 (ACE2) gene therapy improves glycemic control in diabetic mice.
Conclusions- These findings identify ACE2 as a novel target for the prevention of beta-cell dysfunction and apoptosis occurring in type 2 diabetes.
PMID: 20660625 [PubMed - as supplied by publisher] (Source: Diabetes)
A Genetic Link between Obesity and MMP14-Dependent Adipogenic Collagen Turnover.
Conclusions - Together, these findings demonstrate that the MMP14 gene, encoding the dominant pericellular collagenase operative in vivo, directs obesogenic collagen turnover and is linked to human obesity traits.
PMID: 20660624 [PubMed - as supplied by publisher] (Source: Diabetes)
Diabetes Drug Byetta Linked to Kidney Problems by FDA
Byetta, a commonly prescribed diabetes drug, has been linked to kidney and pancreas problems. (Source: Disabled World)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Diabetics can be identified in an electronic medical record using laboratory tests and prescriptions
Source: Tu K et al, Journal of Clinical Epidemiology, 2010 Content: Objective
With the increasing use of electronic medical records (EMRs) comes the potential to efficiently evaluate and improve quality of care. We set out to determine if diabetics could be accurately identified using structured data contained within an EMR.
Study Design and Setting
We used a 5% [...] (Source: ICMCC: The International Council on Medical and Care Compunetics)
Applying Ontology Techniques to Develop a Medication History Search and Alert System in Department of Nuclear Medicine
Source: Chen J et al, Journal of Medical Systems, 2010 Content: Nowadays, patients usually take more than three drugs for diseases such as hypertension, diabetes, and dyslipidemia. Hence, nuclear medicine physicians should be very careful about the medication history of each patient and ensure that their medication will not cause false positive or false negative [...] (Source: ICMCC: The International Council on Medical and Care Compunetics)
Eye study finds two therapies slow diabetic eye disease progression
In high-risk adults with Type 2 diabetes, researchers have found that two therapies may slow the progression of diabetic retinopathy, an eye disease that is the leading cause of vision loss in working-age Americans. (Source: ScienceDaily Headlines)
Morning test helps doctors save kidneys
A morning urine test is superior to all other tests for detecting declining kidney performance in patients with diabetic kidney disease, according to a new study. The results suggest that clinicians should monitor kidney function by measuring the albumin:creatinine ratio from a first morning urine sample. (Source: ScienceDaily Headlines)
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What Is Diabetes Mellitus ? By Juliet Cohen Diabetes mellitus is defined as a fasting blood glucose of 126 milligrams per deciliter (mg/dL) or more. "Pre-diabetes" is a condition in which blood glucose levels are higher than normal but not yet diabetic. can cause many complications. Acute complications (hypoglycemia, ketoacidosis or nonketotic hyperosmolar coma) may occur if the disease is not adequately controlled. Serious long-term complications include cardiovascular disease (doubled risk), chronic renal failure (diabetic nephropathy is the main cause of dialysis in developed world adults), retinal damage (which can lead to blindness and is the most significant cause of adult blindness in the non-elderly in the developed world), nerve damage (of several kinds), and microvascular damage, which may cause erectile dysfunction (impotence) and poor healing. Poor healing of wounds, particularly of the feet, can lead to gangrene which can require amputation - the leading cause of non-traumatic amputation in adults in the developed world. Diabetes is the third leading cause of death in the United States after heart disease and cancer. Over time, can lead to blindness, kidney failure, and nerve damage. These types of damage are the result of damage to small
vessels, referred to as microvascular disease. is also an important factor in accelerating the hardening and narrowing of the arteries (atherosclerosis), leading to strokes, coronary heart disease, and other large blood vessel diseases. This is referred to as macrovascular disease. affects approximately 17 million people (about 8% of the population) in the United States. In addition, an estimated additional 12 million people in the United States have and don't even know it. Normally, blood glucose levels are tightly controlled by insulin, a hormone produced by the pancreas. Insulin lowers the blood glucose level. Non-insulin-dependent mellitus (NIDDM)-is due to a combination of defective insulin secretion and insulin resistance or reduced insulin sensitivity (defective responsiveness of tissues to insulin), which almost certainly involves the insulin receptor in cell membranes. In the early stage the predominant abnormality is reduced insulin sensitivity, characterized by elevated levels of insulin in the blood. Gestational also involves a combination of inadequate insulin secretion It develops during pregnancy and may improve or disappear after delivery. Even though it may be transient, gestational may damage the health of the fetus or mother, and about 20%-50% of women with gestational develop type 2 later in life.Gestational mellitus (GDM) occurs in about 2%-5% of all pregnancies. Juliet Cohen writes articles for health care guide. She also writes articles for women health and health diseases.
Here are some more diabetes articles...
Rock Of Love: Dealing With Diabetes
By Groshan Fabiola
Fans of the VH1 reality television series Rock of Love follow the pursuits and antics of numerous women as they compete and try to win the heart of rock star Bret Michaels. The glam metal performer Read more...
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Good Foods For Great Results
By Ambrose Hutson
You are what you eat. It's more than an adage, it's the truth. If you want to get the most out of your body, you've got to know which foods to choose, and have the dedication to follow a smart diet Read more...
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Salmon Recipes: Valuable Source Of Omega-3 And The Ultimate Gastronomical Delight!
By Betty Mouat
Salmon Recipes have emerged as a hot favorite among countless fish-food lovers across the globe. If you are looking to include some flavorsome dishes in your diet but don’t want to gain weight, Read more...
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