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People with diabetes are at particular risk for severe foot infections, due to impaired circulation, and must take special precautions.

Could you have diabetic kidney disease and not even know it?
Questions to ask your doctor.

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Diabetes is the leading cause of chronic kidney disease

Chronic kidney disease (CKD) is on the rise in part because diabetes is on the rise. If you are at risk for diabetes or have been recently diagnosed with the disease, here’s what you should know about the link between diabetes and CKD.

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Diabetes and minorities: What are the risks?

Some ethnic groups develop diabetes at two to six times the rate of whites. If you are African American, Hispanic, Native American, Asian or Pacific Islander, here’s what you should know about your risk for diabetes.

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Preventing chronic kidney disease when you have diabetes

Diabetes is the leading cause of chronic kidney disease. Keeping diabetes in check and early diagnosis of kidney disease could help decrease the chances of developing kidney failure.

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Diet tips for diabetics with kidney disease

When diabetes leads to kidney disease the goal is to preserve kidney function as long as possible and manage diabetes. What you eat can affect both your blood sugar and your kidney function. A dietitian will work with you to create an eating plan that's right for you, probably using some of the diet tips presented here.

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Introduction

Definition, causes and symptoms
All about diabetes Definition, causes and symptoms What is diabetes? Diabetes is a disease that affects your body?s ability to produce or use insulin. Insulin is a hormone. When your body turns the food you eat into energy (also called sugar or glucose), insulin is released to help transport this energy to th

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Controlling diabetes
Diabetes is the leading cause of chronic kidney disease in the United States. By controlling diabetes through lifestyle choices such as diet and exercise, taking prescribed medicines and seeing a doctor regularly, people with diabetes can usually maintain a healthy lifestyle and help prevent chronic kidney disease and kidney failure. Find out what you can do to control diabetes.

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Diabetes and chronic kidney disease

Diabetes is the leading cause of chronic kidney disease in America. Many people with diabetes are not aware that chronic kidney disease can lead to kidney failure. However, having diabetes does not necessarily mean you will have kidney failure. Learn about the diabetes and kidney disease connection and how you can keep your kidneys healthy.

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Preventing diabetic kidney disease
All about diabetes Preventing diabetic kidney disease How can I slow the progression of kidney disease? Keeping healthy is the most important part of delaying kidney disease. If you have diabetes and have been diagnosed with an early stage of chronic kidney disease, following your doctor?s instructions regard

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Get the facts

Are you in control of your diabetes?
If you have diabetes, your doctor advises you to keep your glucose levels in a healthy range. One of the problems that can occur for diabetics who don’t control their diabetes is the risk of kidney disease which may lead to kidney failure and dialysis. Diabetes is the leading cause of kidney disease in America. Learn how you can control your diabetes to avoid other health complications such as renal disease.

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Diabetic nephropathy
Image: Diabetic nephropathy

Diabetic nephropathy means kidney damage that occurs as a result of diabetes. Researchers believe poor control of blood sugar or blood glucose levels is one of the reasons people with diabetes develop this type of kidney disease. Learn about diabetic nephropathy symptoms, diagnosis and treatment.

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Diabetes and peritoneal dialysis
diabetes and pd 340x160

Diabetes mellitus is the number one cause of kidney failure in the United States, leading many people to need dialysis. Learn about the relationship between diabetes and chronic kidney disease (CKD), as well as how people with diabetes can choose to do the home dialysis treatment, peritoneal dialysis (PD).

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diabetes and pd

diabetes and pd 340x160

A Breakthrough In Comprehensive Home Testing
By Richard Shames, M.D. & Karilee Shames, Ph.D., R.N.

Amid book tour, lectures, and coaching, we have had the distinct opportunity in recent months to talk individually with health consumers from all over the country. There is a recurring theme (which to many of you will be no surprise) that doctors, especially endocrinologists, are not listening to you. We have known of this dilemma for years, but what's news is just how pervasive and persistent this problem is!

The endocrinologists especially seem perhaps overwhelmed with care, resulting in less-than-proper numbers of people being diagnosed with other hormonal challenges, and furthermore resulting in less-than-optimal care for those who are diagnosed. So what are you to do to achieve a better result?

One of the main reasons that borderline thyroid sufferers are not getting diagnosed is the tyranny of the TSH test, coupled with the fact that blood tests in general do not always reflect the true metabolic state. Often, our true hormonal levels are better represented by measurement from the tissues themselves (where hormones take their action), rather than measuring the bloodstream (where hormones are inactive and tightly bound to transport proteins). A simple home test, not by blood but rather with blood spot, can frequently yield a different and more representative result.

In our SF Bay area clinic, a number of people with severe thyroid symptoms [who were either not diagnosed or not adequately treated] found that salivary testing became the deciding factor in improving their care. Particularly for those with borderline conditions, this testing-now available without a doctor's prescription- can more readily pinpoint subtle imbalances. These tests can be ordered at a discount from www.canaryclub.org.

Another major reason for misdiagnosis and inadequate treatment is the crucial issue of concurrent adrenal and/or sex hormone insufficiency. Truly advanced thyroid care involves an accurate evaluation of adrenal and reproductive hormones, since these glands coupled with thyroid constitute an important metabolic triad.

As you know, excess estrogen is anti-thyroid; the more estrogen increases, the more thyroid-binding globulin is in your bloodstream. This keeps your blood readings for thyroid hormone high, but your tissues actually starved for thyroid hormone. Your blood tests may look good, while you continue to feel lousy.

Also keep in mind that the very important conversion of T4 into active thyroid hormone (T3) requires the right amount of adrenal hormone. Too much - or too little - cortisol interferes with this important conversion mechanism. Some researchers suggest that proper levels of cortisol are needed for thyroid to enter our cells from the bloodstream in the first place.

Standard blood tests are often surprisingly poor measurements of the level of adrenal and sex hormones in the tissues. Much more accurate determinations are made via saliva, which

Effects of Nordic Walking and Exercise on Glucose Metabolism in Type 2 Diabetes Mellitus: A Randomized Controlled Trial
Conditions: Type 2 Diabetes; Exercise Interventions: Behavioral: Exercise on Prescription; Behavioral: Nordic Walking Sponsors: Hospital of South West Denmark; University of Southern Denmark Completed - verified January 2005
NOX-E36 Multiple Ascending Dose Study in Healthy Volunteers and Patients With Type 2 Diabetes Mellitus
Condition: Type 2 Diabetes Mellitus Interventions: Drug: NOX-E36; Drug: NOX-E36 Sponsors: Noxxon Pharma AG; Profil Institut für Stoffwechselforschung GmbH Not yet recruiting - verified March 2010
The Effect of a Gastric Bypass on Type 2 Diabetes in the Morbidly Obese Patient
Conditions: Type 2 Diabetes; Morbid Obesity Intervention: Sponsor: University Hospital, Gasthuisberg Recruiting - verified March 2010
Does Green Tea Affect Postprandial Glucose, Insulin and Satiety in Healthy Subjects
Conditions: Diabetes Type 2; Obesity Intervention: Sponsor: Malmö University Hospital Completed - verified December 2009
Biomarkers of Metabolic Syndrome and Prediabetes
Conditions: Metabolic Syndrome; Diabetes; Prediabetes; Hypertension Intervention: Sponsor: West Virginia School of Osteopathic Medicine Not yet recruiting - verified March 2010
Effect of Testosterone on Endothelial Function and Microcirculation in Type 2 Diabetic Patients With Hypogonadism
Conditions: Type 2 Diabetes; Hypogonadism Intervention: Drug: Testosterone Sponsor: Tameside Hospital NHS Foundation Trust Not yet recruiting - verified November 2008
Study to Find Out if Intensive Diabetes Clinic and Continuous Glucose Monitors Help Teenagers With Diabetes
Condition: Type 1 Diabetes Mellitus Interventions: Behavioral: Diabetes related psychological counseling and education; Device: Continuous Glucose Monitor Sponsors: University Hospital Case Medical Center; National Institute of Mental Health (NIMH) Not yet recruiting - verified March 2010
Efficacy and Safety of Linagliptin in Elderly Patients With Type 2 Diabetes
Condition: Diabetes Mellitus, Type 2 Interventions: Drug: linagliptin; Drug: placebo Sponsor: Boehringer Ingelheim Pharmaceuticals Recruiting - verified March 2010
To Evaluate the Effect of Gemfibrozil on the Pharmacokinetics and Pharmacodynamics of a Single Dose of AZD1656
Condition: Type 2 Diabetes Mellitus Interventions: Drug: AZD1656; Drug: Gemfibrozil; Drug: Placebo Sponsor: AstraZeneca Not yet recruiting - verified March 2010
Effects of Caloric Restriction Alone Versus Postoperative Caloric Restriction Following Bariatric Surgery on Glucose Metabolism in Patients With Diabetes Mellitus
Conditions: Obesity; Bariatric Surgery; Morbid Obesity; Diabetes Mellitus Type 2; Diet Therapy Interventions: Procedure: Roux-en-Y Gastric Bypass; Behavioral: Caloric Restriction Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Recruiting - verified February 2010
Investigate the Effect of AZD1656 on the Pharmacokinetics of Pioglitazone and Vice Versa in Type 2 Diabetes Mellitus
Condition: Type 2 Diabetes Mellitus Interventions: Drug: AZD1656; Drug: Pioglitazone Sponsor: AstraZeneca Recruiting - verified March 2010
The CANTATA-M (CANagliflozin Treatment and Trial Analysis - Monotherapy) Trial
Condition: Diabetes Mellitus, Type 2 Interventions: Drug: Canagliflozin 100 mg; Drug: Placebo/sitagliptin 2x50 mg; Drug: Canagliflozin 300 mg Sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Recruiting - verified March 2010
Insulin Glargine for Diabetes Metabolism(DM)Type II Patients Under Enteral Nutrition
Condition: Diabetes Mellitus, Type 2 Interventions: Drug: INSULIN GLARGINE; Drug: INSULIN GLULISINE Sponsor: Sanofi-Aventis Recruiting - verified March 2010
Lifestyle Intervention to Limit Excessive Weight Gain During Pregnancy in Minority Women
Conditions: Pregnancy; Weight Gain Interventions: Behavioral: Lifestyle Intervention group; Behavioral: Standard of Care Sponsor: Emory University Not yet recruiting - verified March 2010
Comparing Google With A Focused Diabetes Search Engine
Condition: Diabetes Intervention: Sponsor: Beth Israel Deaconess Medical Center Recruiting - verified March 2010
Continuous Glucose Monitoring in Type 2 Diabetes Mellitus
Condition: Diabetic Vascular Complications Intervention: Sponsor: Winthrop University Hospital Recruiting - verified March 2010
Comparison of NN1250 With Insulin Glargine in Type 1 Diabetes
Condition: Diabetes Mellitus, Type 1 Interventions: Drug: NN1250; Drug: insulin glargine; Drug: NN1250; Drug: insulin aspart Sponsor: Novo Nordisk Recruiting - verified March 2010
Clinical Trial of SB-509 in Subjects With Diabetic Neuropathy
Conditions: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Polyneuropathy Interventions: Drug: SB-509; Other: Saline Sponsors: Sangamo Biosciences; Juvenile Diabetes Research Foundation Recruiting - verified March 2010
A Culturally Tailored Lifestyle Intervention to Prevent Diabetes in South Asians
Conditions: Diabetes; Obesity Intervention: Behavioral: Lifestyle Intervention Classes Sponsors: Emory University; American Diabetes Association; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Not yet recruiting - verified January 2010
Corneal Endothelial Changes Associated With Phacoemulsification in Diabetes Mellitus Type II
Conditions: Diabetes; Cataract Intervention: Sponsor: Frederiksberg University Hospital Completed - verified August 2009
Effectiveness and Tolerability of Tarka® in the Treatment of Hypertensive Patients With High Risk of Developing Diabetes Mellitus
Condition: Hypertension Intervention: Sponsor: Abbott Completed - verified March 2010
Impact of Computerized Decision Support on Racial/Ethnic Disparities in Hypertension Outcomes
Condition: Hypertension Intervention: Other: Computerized reminders on hypertension intensification Sponsors: Brigham and Women's Hospital; Robert Wood Johnson Foundation Not yet recruiting - verified March 2010
Intraarterial Infusion of Autologous Mesenchymal Stem Cells From Adipose Tissue in Diabetic Patients With Chronic Critical Limb Ischemia
Conditions: Diabetes; Limb Ischemia Interventions: Other: Autologous mesenchymal stem cells from adipose tissue.; Other: Autologous mesenchymal stem cells from adipose tissue.; Other: Autologous mesenchymal stem cells from adipose tissue. Sponsors: Fundacion Progreso y Salud, Spain; Carlos III Health Institute Recruiting - verified January 2010
Reducing HIV Risk Among Mexican Youth
Conditions: HIV/AIDS; STD; Sexual Behavior Interventions: Behavioral: Adolescent Safer Sex Intervention; Behavioral: Parent Safer Sex Communication Intervention; Other: Adolescent Health Promotion Control Condition; Other: Parent Health Promotion Control Condition Sponsors: University of Michigan; National Institute of Nursing Research (NINR) Completed - verified March 2010
Cytochrome P450 2C19 Variant is Related to Pharmacokinetics of Glipizide Extended Release Tablet in Chinese Subjects
Conditions: Genotype; Pharmacokinetic Intervention: Drug: Glipizide Sponsors: Chinese Academy of Sciences; The First Affiliated Hospital of Lanzhou University Completed - verified November 2009
Role of Vitagliptin and Vitamin D in the Treatment of Non Alcoholic Fatty Liver Disease (NAFLD)
Condition: Non-Alcoholic Fatty Liver Disease Interventions: Drug: Galvus (vitagliptin); Drug: Galvus + vitamin D Sponsor: Ziv Hospital Not yet recruiting - verified March 2010
Use of Topical Lidocaine to Reduce Pain in Patients With Diabetic Neuropathy
Condition: Diabetic Peripheral Neuropathy Interventions: Other: Skin biopsy; Other: Skin biopsy Sponsors: Albany Medical College; Endo Pharmaceuticals Recruiting - verified March 2010
Adolescent Cooking and Eating Study
Condition: Polycystic Ovary Syndrome Intervention: Behavioral: Nutrition Education, Dietary Counseling, and Cooking Sponsors: Children's Hospital Boston; Thrasher Research Fund Not yet recruiting - verified March 2010
Midfoot Fusion Bolt (MFB) in the Early Stage of Diabetic-neuropathic Charcot Feet
Conditions: Diabetes Mellitus 1 or 2; Midfoot Charcot Neuroarthropathy Interventions: Procedure: Surgery with Midfoot Fusion Bolt; Procedure: Cast treatment Sponsor: AO Clinical Investigation and Documentation Not yet recruiting - verified March 2010
An Observational Study Investigating the Safety and Effectiveness of Repaglinide in Chinese Patients
Condition: Diabetes Mellitus, Type 2 Intervention: Drug: repaglinide Sponsor: Novo Nordisk Not yet recruiting - verified February 2010
Ranibizumab for Edema of the mAcula in Diabetes: Protocol 3 With High Dose - the READ 3 Study
Condition: Diabetic Macular Edema Interventions: Drug: Ranibizumab; Drug: ranibizumab Sponsors: Johns Hopkins University; Juvenile Diabetes Research Foundation Recruiting - verified February 2010
Effects of Pravastatin on Cholesterol, Inflammation and Cognition in Schizophrenia
Conditions: Schizophrenia; Schizoaffective Disorders; Schizophreniform Disorders Interventions: Drug: Pravastatin; Drug: Placebo Sponsors: Massachusetts General Hospital; Stanley Medical Research Institute Not yet recruiting - verified March 2010
Healthy Homes/Healthy Kids_5-9
Conditions: Obesity; Injury Interventions: Behavioral: Healthy Eating/Physical Activity; Behavioral: Safety/Injury Prevention Sponsors: HealthPartners Research Foundation; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); University of Washington; University of Minnesota School of Public Health Not yet recruiting - verified March 2010
Canadian Study of Trandolapril on Blood Pressure in Hypertensive Patients
Condition: Hypertension Intervention: Sponsors: Abbott; McKesson Canada Recruiting - verified February 2010
Pilot Pharmacokinetic Study of Daily Versus Monthly High-Dose Cholecalciferol Supplementation
Condition: Healthy Volunteers Interventions: Dietary Supplement: Single High Dose Cholecalciferol; Dietary Supplement: Daily Dose Cholecalciferol Sponsor: Mayo Clinic Recruiting - verified March 2010
Effects of N-acetylcysteine on Diabetic Foot Oxygenation
Condition: Foot Ulcer, Diabetic Intervention: Drug: N-acetylcysteine Sponsor: University of Turin, Italy Completed - verified February 2010
Self Management and Reminders With Technology: SMART Appraisal of an Integrated Personal Health Record (PHR)
Condition: Cardiovascular Risk Interventions: Other: SMART PHR; Other: usual care Sponsors: University of Pittsburgh; Agency for Healthcare Research and Quality (AHRQ) Not yet recruiting - verified March 2010
Canakinumab in the Treatment of Acute Gout Flares and Prevention of New Flares in Patients Unable to Use NSAIDs and/or Colchicines.
Condition: Acute Gout Interventions: Drug: ACZ885; Drug: Triamcinolone acetonide Sponsor: Novartis Pharmaceuticals Not yet recruiting - verified March 2010
Healthy Homes/Healthy Kids Preschool
Condition: Obesity Interventions: Behavioral: Busy Bodies/Better Bites; Behavioral: Healthy Spots/Safe Tots Sponsors: HealthPartners Research Foundation; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Not yet recruiting - verified March 2010
Study of Capsule Endoscopy to Determine the Accuracy for Detection of Esophageal Varices
Condition: Esophageal Varices Intervention: Device: Capsule endoscopy, Esophagogastroduodenoscopy Sponsors: University of California, Los Angeles; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Completed - verified June 2008
Study of Ischemic Colitis Compared to Other Diagnoses in Patients With Lower Gastrointestinal Bleeding
Condition: Colitis, Ischemic Intervention: Sponsors: University of California, Los Angeles; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Completed - verified December 2009

is a truer representation of the amount of free and available hormone.

For these reasons, we would like to invite each of you to participate in a consumer-advocacy group (www.CanaryClub.org) that will help you measure more accurately the level of thyroid, adrenal, and sex hormones currently in your tissues. The Canary Club was started by two courageous California women who had been through the mill with ineffective testing resulting in inadequate care. They are now ready and willing to work with you to create an effective vehicle for healthy change.

This group allows people from all over the country to self-order a home hormone test kit for concurrent evaluation of these three major hormones.

Please realize that we are not suggesting you forego any blood testing you - or your doctor - might want to order. We're simply recommending that, in addition to whatever regular care you have received so far, you might want to further evaluate your thyroid, adrenal, and reproductive hormone status via home saliva and blood spot testing.

You can order your home test kit simply by logging onto the site (www.CanaryClub.org ), becoming a member (it's free), and ordering a test kit.

How to interpret your results is the title of a separate article posted on the Canary Club website. More interpretation and treatment information is available in our book FEELING FAT, FUZZY OR FRAZZLED? (Penguin/Hudson St. Press 2005).

And - for those very difficult problems, we are available for telephone appointments and advanced thyroid coaching via our website www.FeelingFFF.com (click on appointments) should that be necessary.

Most of the time, however, the information from your results can be very useful to you and your practitioners, helping you to either move into a thyroid diagnosis with an accompanying treatment program, or to enhance your current protocol if you have been diagnosed but would like to feel even better.

We hope you take advantage of this exciting new opportunity. This is the same testing we use at our Preventive Medicine Center of Marin offices, where we both see individual patients in San Rafael, CA. This type of testing is being increasingly utilized by health practitioners from all over the country (except the state of New York, which does not yet allow access to saliva testing.

Finally, we encourage each of you to become engaged in other activities of the Canary Club, a health organization that will allow thyroid sufferers to create a collective and mighty voice for change. Currently pollution is wrecking the thyroid balance of our society; our new book discusses this epidemic. A great many synthetic chemicals in the air, food and water are significant hormone disruptors, slowing down our delicate thyroid function. There is a lot we can do about this, both individually and collectively.

Please join the www.Canaryclub.org chorus, maybe even become a local group leader, and help to inspire the needed changes to reverse this epidemic. There are 40-50 million Americans facing these environmentally-induced (genetically enhanced) gland problems.

Together we can reclaim our health, and our environment. Speak out now!

*****

Article Directory: http://www.articlecube.com

The Canary Club was started by Lynn Larkin and Judith Seton, two women who had been through the mill with ineffective testing resulting in inadequate care. They are now ready and willing to work with you to create an effective vehicle for healthy change. We would like to invite each of you to participate in a consumer-advocacy group (www.CanaryClub.org) that allows people from all over the country to self-order a home hormone test kit for concurrent evaluation of these three major hormones. Drs Shames can be reached at www.FeelingFFF.com

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Exercising just got easier for busy people, study shows
(McMaster University) Researchers have found that interval training does not have to be "all out" to be effective in helping reduce the risk of such diseases at Type 2 diabetes. (Source: EurekAlert! - Social and Behavioral Science)
Asymmetric Large-for-Gestational-Age Infants of Type 1 Diabetic Women: Morbidity and Abdominal Growth
Amer J PerinatolDOI: 10.1055/s-0030-1249362ABSTRACTWe sought to examine neonatal morbidity in four groups of offspring (asymmetric large for gestational age [LGA], symmetric LGA, asymmetric non-LGA, symmetric non-LGA) exposed in utero to maternal type 1 diabetes, and the association between rate of fetal abdominal circumference growth and asymmetric LGA. We performed a secondary analysis of 302 singleton pregnancies. Neonatal morbidity (respiratory distress syndrome, polycythemia, hypoglycemia, hyperbilirubinemia, acidosis, and composite morbidity [any of the five]) was assessed. Serial ultrasound examinations after 20 weeks' gestation were available for 35 fetuses. Logistic regression and general linear mixed modeling were used for analysis. Asymmetric LGA infants had 3.5-, 2.2-, and 3.2-...
Diabetes Link to Eating Disorders
Diabetics, under the gun to better manage their disease by controlling their food intake and weight, may find themselves in the sticky wicket of needing treatment that makes them hungry, researchers said. (Source: Disabled World)<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Glycemic index diet: A helpful tool for diabetes?
Some people with diabetes use the glycemic index (GI) as a guide in selecting foods. (Source: MayoClinic.com - Ask a Specialist)
Diabetes and Cognitive Decline: Investigating the Potential Influence of Factors Related to Health Disparities
Discussion: Findings suggest that factors related to health disparities may influence cognitive outcomes among older adults with diabetes. (Source: Journal of Aging and Health)
[Viewpoint] The role of academic health science systems in the transformation of medicine
The challenges facing the health of communities around the world are unprecedented, and the data are all too familiar. For 5 billion people living in developing countries, environmental factors and inadequacies in hygiene, economic development, and health-care access are the main causes of shortened life expectancies. Improvements in health status, including reductions in infant mortality and declining incidence of infectious diseases, are being met by the new epidemics of obesity, diabetes mellitus, and cardiovascular disease. (Source: LANCET)
Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats.
Conclusion: Excessive dietary fat and/or increased levels of luminal bile juice, but not genetic obesity, are responsible for the increase in small intestinal permeability resulting from the suppression of TJ protein expression. (Source: Nutrition & Metabolism)
Use of pegaptanib for recurrent and non-clearing vitreous haemorrhage in proliferative diabetic retinopathy
Authors: D Hornan, N Edmeades, R Krishnan, J Khan & J Lochhead (Source: Eye)<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY)
Conclusion: Mutations in INS can be a rare cause of MODY and we conclude that screening for mutations in INS should be recommended in MODYX patients. (Source: BMC Medical Genetics - Latest articles)
Oxidative and Nitrosative Stress and Progression of Diabetic Nephropathy in Type 2 Diabetes
Am J Nephrol 2010;31:342–352 (DOI:10.1159/000297290) (Source: Karger Publishers)
Big first trimester weight gain ups diabetes risk
NEW YORK (Reuters Health) - Women who gain weight too quickly during the first three months of pregnancy are more prone to develop pregnancy-related diabetes, new research shows. (Source: Reuters: Health)
Comorbid Diabetes and Depression Increase Dementia Risk
Patients with diabetes and major depression have a markedly increased risk of developing dementia compared with their counterparts with diabetes alone. Medscape Medical News (Source: Medscape Today Headlines)
FDA Says No "Clear Connection" Between Bisphosphonate Use and Femur Fracture Risk
FDA Says No "Clear Connection" Between Bisphosphonates, Femur Fracture Risk Medscape Medical News (Source: Medscape Today Headlines)<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Cholesterol, Diabetes Medications Top List of Prescription Drug Expenses for Medicare Recipients
Metabolic agents make up nearly one quarter of all purchases by those aged 65 years and older. Medscape Medical News (Source: Medscape Today Headlines)
Long-Acting Insulin Analogs May up Risk of Diabetic Ketoacidosis in Children
Use of insulin glargine or detemir rather than NPH insulin does not reduce the risk of ketoacidosis in children and adolescents with type 1 diabetes, and in fact may increase the risk, a new study shows. Reuters Health Information (Source: Medscape Diabetes Headlines)
Overview on practices in thalassemia intermedia management aiming for lowering complication rates across a region of endemicity: the OPTIMAL CARE study
This study provides evidence that calls for prospective evaluation of the roles of transfusion, iron chelation, and hydroxyurea therapy in TI patients. (Source: Blood)
Adherence Studies in Adolescents with Chronic Kidney or Urologic Diseases, or Diabetes (R01)
Funding Opportunity Number: RFA-DK-10-004 Opportunity Category: DiscretionaryFunding Instrument Type: GrantCategory of Funding Activity: Food and NutritionHealthCFDA Number: 93.847Eligible Applicants State governmentsCounty governmentsCity or township governmentsSpecial district governmentsIndependent school districtsPublic and State controlled institutions of higher educationNative American tribal governments (Federally recognized)Public housing authorities/Indian housing authoritiesNative American tribal organizations (other than Federally recognized tribal governments)Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher educationNonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher educationPrivate instit...
World Kidney Day Podcast
The focus on diabetic kidney disease for World Kidney Day 2010 brings awareness of the magnitude of the problem and ramifications for global health for people with diabetes and kidney disease. It is therefore time to act and act urgently. It is time for strategies that prevent diabetes and its sequelae. It is time for programs for health care workers to diagnose and treat people with diabetic kidney disease. It is time for governments to pass legislation to enable the diabetes pandemic to be controlled. After all, diabetic kidney disease, like the epidemics of infectious diseases that have long dominated public health agendas, is potentially preventable. Indeed, March 11, 2010 is time to act on diabetic kidney disease and to commit to sustaining that action long after World Kidney Day. Li...<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
2009 H1N1 Influenza and its Impact on People with Chronic Medical Conditions: Questions and Answers
The January 12, 2010 National Influenza Vaccination Week Webinar featured Dr. Nicole Lurie with the US Department of Health and Human Services; Dr. Anthony Fiore with Centers for Disease Control and Prevention; Dr. Otis Webb Brawley with American Cancer Society; Christine Tobin with American Diabetes Association; and Mary Partridge with the American Lung Association. (Source: PandemicFlu.gov RSS Feed for News Releases)
Metabolic Meds Top Medicare Drug Spending
Metabolic drugs (MedPage Today) -- namely cholesterol and diabetes meds -- account for the greatest Medicare prescription expenses, researchers say. (Source: MedPage Today Public Health)
Foods high in meat and fat confer increased risk for diabetes in all ethnic groups
Foods high in meat and fat appear to confer an increased risk for diabetes in all ethnic groups, whereas the effects of other dietary patterns vary by gender and ethnicity, say US researchers. (Source: MedWire News - Diabetes)
Descending Necrotising Mediastinitis, A Fatal Disease to Keep in Mind
We report an unusual case of primary retropharyngeal abscess complicated by descending necrotising mediastinitis and bilateral empyema in a 56-year-old diabetic man. The diagnosis of descending necrotising mediastinitis (DNM) was established by the characteristic findings on computed tomography. The patient was treated by cervicotomy and staged bilateral posterolateral thoracotomy. (Source: Heart, Lung & Circulation)
Impact of Chronic Kidney Disease on Platelet Function Profiles in Diabetes Mellitus Patients With Coronary Artery Disease Taking Dual Antiplatelet Therapy
Conclusions: In DM patients with coronary artery disease taking maintenance aspirin and clopidogrel therapy, impaired renal function is associated with reduced clopidogrel-induced antiplatelet effects and a greater prevalence of HPPR. (Source: Journal of the American College of Cardiology)<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Determinants of Coronary Calcium Conversion Among Patients With a Normal Coronary Calcium Scan: What Is the ?Warranty Period? for Remaining Normal?
Conclusions: Among individuals with CAC = 0, conversion to CAC >0 is nonlinear and occurs at low frequency before 4 years. No clinical factor seems to mandate earlier repeat CAC scanning. (Source: Journal of the American College of Cardiology)
Single and unhappily married men are at 64% higher risk of dying from stroke
Men who were single in the 1960s were 64% more likely to suffer a fatal stroke over the next three decades than their married counterparts.The risk of fatal stroke was also 64% higher in men who reported dissatisfaction with their marriages than in men who rated their marriages as successful.That figure is comparable to the risk of fatal stroke faced by men with diabetes.References:Single Men Have Higher Risk of Stroke. WebMD.Image source: CT scan slice of the brain showing a right-hemispheric ischemic stroke (left side of image). Wikipedia, GNU Free Documentation License. Posted at Clinical Cases and Images. Stay updated and subscribe, follow on Twitter and Buzz, and connect on Facebook. (Source: Clinical Cases and Images)
Medical care costs among patients with established cardiovascular disease.
CONCLUSIONS: The economic burden of providing care to patients with CVD may be substantially greater than current American Heart Association estimates. Although several comorbid conditions undoubtedly contribute to these costs, avoidance of secondary CVD hospitalization may be the key to substantially reducing healthcare consumption. PMID: 20205493 [PubMed - in process] (Source: The American Journal of Managed Care)
Diabetic kidney disease: act now or pay later.
Authors: Atkins RC, Zimmet P PMID: 20213919 [PubMed - in process] (Source: American Journal of Nephrology)
New cholesterol drug tested
Conclusion This is an important and well-conducted trial, which has demonstrated the potential of a drug, eprotirome, to lower cholesterol levels. However, conclusions about the effects of this drug should not be made too prematurely and much further research is needed: So far, use of the drug alone has not been compared to statin treatment. In this trial eprotirome or inactive placebo was only ever given in addition to people?s long-term statins. Therefore no comparison of cholesterol-lowering effect of each of the treatments alone can be made. Only a small number of people were included in the trial: 47 on the 25microgram dose, 46 on 50micrograms, and 44 on the 100microgram dose of eprotirome. These groups of participants are too small to draw any conclusions on the safety or eff...<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Agency For Healthcare Research And Quality News And Numbers: High Cholesterol, Diabetes Lead Drug Spending For The Elderly
Purchases of cholesterol and diabetes prescription drugs by elderly Medicare beneficiaries reached nearly $19 billion in 2007 - about one-fourth of the approximately $82 billion spent for medications for the elderly, according to the latest AHRQ News and Numbers... (Source: Cholesterol News From Medical News Today)
The American Diabetes Association Encourages Community Organizations To Join The Movement To Stop Diabetes
The American Diabetes Association announced today their efforts to further engage community organizations across the country in raising awareness about the seriousness of diabetes and its complications through the Association's Stop Diabetes movement. The American Diabetes Association is rolling out a Stop Diabetes Community Outreach Toolkit to help community and faith-based organizations, health clinics, libraries, hospitals, fraternal groups and corporations raise awareness of diabetes risk factors among their constituents... (Source: Health News from Medical News Today)
Agency For Healthcare Research And Quality News And Numbers: High Cholesterol, Diabetes Lead Drug Spending For The Elderly
Purchases of cholesterol and diabetes prescription drugs by elderly Medicare beneficiaries reached nearly $19 billion in 2007 - about one-fourth of the approximately $82 billion spent for medications for the elderly, according to the latest AHRQ News and Numbers. Metabolic drugs, which are used to lower cholesterol levels, keep diabetes under control and for weight and thyroid problems, topped the list of the five leading categories of drugs purchased by the elderly... (Source: Health News from Medical News Today)
Glycated Hemoglobin Tests See Increasing Use
Glycated hemoglobin (HbA1c) testing is one of the success stories of point-of-care diagnostics, and an area that will experience higher growth rates than other POC tests as a result of expert recommendations, new cases and booming mail-in test sales, according to the new report "Point-of-care Diagnostics 2010 and Beyond: Rapid Testing at a Crossroads," by healthcare market research publisher Kalorama Information. The test measures glucose attached to the blood protein hemoglobin, a well-established analyte related to the long-term evaluation of blood sugar control... (Source: Health News from Medical News Today)
The American Diabetes Association Encourages Community Organizations To Join The Movement To Stop Diabetes
The American Diabetes Association announced today their efforts to further engage community organizations across the country in raising awareness about the seriousness of diabetes and its complications through the Association's Stop Diabetes movement... (Source: Diabetes News From Medical News Today)<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Glycated Hemoglobin Tests See Increasing Use
Glycated hemoglobin (HbA1c) testing is one of the success stories of point-of-care diagnostics, and an area that will experience higher growth rates than other POC tests as a result of expert recommendations, new cases and booming mail-in test sales, according to the new report "Point-of-care Diagnostics 2010 and Beyond: Rapid Testing at a Crossroads," by healthcare market rese... (Source: Diabetes News From Medical News Today)
Recent Studies Link Obesity To Food Allergies
First Lady Michelle Obama's "Let's Move" Campaign tells us that about 32 percent of children and teens (or 25 million) are obese or overweight. It revealed those extra pounds put them at greater risk of developing debilitating and costly diseases including diabetes, high blood pressure and high cholesterol and may also cause them to lead a two to five year shorter life than their parents... (Source: Health News from Medical News Today)
Recent Studies Link Obesity To Food Allergies
First Lady Michelle Obama's "Let's Move" Campaign tells us that about 32 percent of children and teens (or 25 million) are obese or overweight. It revealed those extra pounds put them at greater risk of developing debilitating and costly diseases including diabetes, high blood pressure and high cholesterol and may also cause them to lead a two to five year shorter life than their parents... (Source: Allergy News From Medical News Today)
No mortality benefit in reducing HbA1c below 9%
There is little to gain in terms of reduced mortality from continually lowering HbA1c targets in patients with type 2 diabetes, a Dutch study has concluded. (Source: Pulse)
Frequent napping linked to increased risk of type 2 diabetes in older adults
A study shows that frequent napping is associated with an elevated prevalence of type 2 diabetes and impaired fasting glucose in an older Chinese population. (Source: ScienceDaily Headlines)<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Cardiac Catheterizations: Too Many Performed?
Title: Cardiac Catheterizations: Too Many Performed?Category: Health NewsCreated: 3/11/2010 10:14:00 AMLast Editorial Review: 3/11/2010 10:14:51 AM (Source: MedicineNet Diabetes General)
Glycemic index diet: A helpful tool for diabetes?
Some people with diabetes use the glycemic index (GI) as a guide in selecting foods. (Source: MayoClinic.com Full Feed)
New alterations found in young adults with type 2 diabetes
(Institute for Research in Biomedicine (IRB Barcelona)) Diet and aerobic exercise are highly effective for the treatment of type 2 diabetes, but not for obese subjects that have developed the disease when very young. A study at the IRB Barcelona and Trinity College in Dublin demonstrates that obese subjects between 18 and 25 years of age carry mitochondrial proteins and genes that work abnormally and that these anomalies contribute to generating insulin resistance and a reduced response to physical exercise. (Source: EurekAlert! - Medicine and Health)
Insurers Test Health Plans that Stress Patient Choices
Workers at a Portland, Ore., steel mill soon will be able to pick a new type of insurance that offers free care for some illnesses, such as diabetes or depression, but requires hefty extra fees for treatments deemed overused, including knee replacements, hysterectomies and heart bypass surgery. (Source: RWJF News Digest - Quality/Equality)
New alterations found in young adults with type 2 diabetes
Diet and aerobic exercise are highly effective for the treatment of type 2 diabetes, but not for obese subjects that have developed the disease when very young. A new study demonstrates that obese subjects between 18 and 25 years of age carry mitochondrial proteins and genes that work abnormally and that these anomalies contribute to generating insulin resistance and a reduced response to physical exercise. (Source: ScienceDaily Headlines)<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Diabetes' link to eating disorders explored
(Medical College of Georgia) Diabetics, under the gun to better manage their disease by controlling their food intake and weight, may find themselves in the sticky wicket of needing treatment that makes them hungry, researchers said. (Source: EurekAlert! - Biology)
Body's anticipation of a meal can be a diabetes risk factor
(Duke University Medical Center) Alterations in our response to the taste or smell of food may be another culprit responsible for Type 2 diabetes, according to scientists at Duke University Medical Center who have identified the specific mechanism in human specimens and in mice. (Source: EurekAlert! - Medicine and Health)
Depression plus diabetes may = dementia
SEATTLE, March 10 (UPI) -- Diabetes combined with depression increases dementia risk, University of Washington researchers found. (Source: Health News - UPI.com)
Measurement of Adiponectin Production from Differentiated Metabolic Stem Cells
Horm Metab ResDOI: 10.1055/s-0030-1248304AbstractTo treat metabolic syndrome, fat tissue dysfunction should be corrected rather than controlling conventional risk factors such as hypertension, dyslipidemia, and diabetes mellitus. For this purpose, accumulating evidence suggests increasing plasma adiponectin levels can be a key treatment strategy, especially in setting of food or drug selection. Here we report that adipocyte precursors obtained from several sites of fat tissue, which we call Metabolic Stem Cells (MSC), could be used as a novel screening system to identify adiponectin enhancing drugs or food for individual patients. MSC were prepared from fat tissues collected from 29 patients. They were differentiated in cultures into mature adipocytes. The time course of adiponectin produc...
ZenBio Licenses An Important Cell Line From Harvard To Drive Metabolic Disease Research
ZenBio announce that they will be a commercial source for the popular murine 3T3-L1 cell line, which has been fundamental in metabolic disease research for 30 years. Originally derived from Swiss mouse embryo tissue by Dr. Howard Green of the Department of Cell Biology at Harvard Medical School, the 3T3-L1 system has been pivotal in advancing the understanding of basic cellular mechanisms associated with diabetes, obesity and other related disorders... (Source: Health News from Medical News Today)<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
An observational study of type 2 diabetes within a large Australian tertiary hospital pediatric diabetes service
Conclusions: At present, T2DM in youth remains a low burden on our services. Patients with this diagnosis, however, have significant problems that present a major challenge to the development of effective management strategies. (Source: Pediatric Diabetes)
Comparison of Humalog Mix 50 with human insulin Mix 30 in type 2 diabetes patients during Ramadan
Conclusion: Changing to humalog Mix 50 during Ramadan resulted in improvement in glycaemic control without increasing the incidence of hypoglycaemia. (Source: International Journal of Clinical Practice)
Identification of bioactive compounds from flowers of black elder (Sambucus nigra L.) that activate the human peroxisome proliferator-activated receptor (PPAR) [ggr]
Obesity is one of the predisposing factors for the development of overt Type 2 diabetes (T2D). T2D is caused by a combination of insulin resistance and [bgr]-cell failure and can be treated with insulin sensitizing drugs that target the nuclear receptor peroxisome proliferator-activated receptor (PPAR) [ggr]. Extracts of elderflowers (Sambucus nigra) have been found to activate PPAR[ggr] and to stimulate insulin-dependent glucose uptake suggesting that they have a potential use in the prevention and/or treatment of insulin resistance. Bioassay-guided chromatographic fractionation of a methanol extract of elderflowers resulted in the identification of two well-known PPAR[ggr] agonists; [agr]-linolenic acid and linoleic acid as well as the flavanone naringenin. Naringenin was found to activa...
Varying recurrence rates and risk factors associated with different definitions of local recurrence in patients with surgically resected, stage I nonsmall cell lung cancer
The objective of this study was to examine the effects of different definitions of local recurrence on the reported patterns of failure and associated risk factors in patients who undergo potentially curative resection for stage I nonsmall cell lung cancer (NSCLC).The study included 306 consecutive patients who were treated from 2000 to 2005 without radiotherapy. Local recurrence was defined either as "radiation" (r-LR) (according to previously defined postoperative radiotherapy fields), including the bronchial stump, staple line, ipsilateral hilum, and ipsilateral mediastinum; or as "comprehensive" (c-LR), including the same sites plus the ipsilateral lung and contralateral mediastinal and hilar lymph nodes. All recurrences that were not classified as "local" were considered to be distal....
NHS Diabetes publishes new guidelines on the management of patients with diabetes
Source: NHS Diabetes Area: News NHS Diabetes have published a range of new publications at the Diabetes UK Annual Professional Conference (please see links below for access to the guidelines):   . Hospital management of hypoglycaemia in adults with diabetes mellitus . Joint British Diabetes Societies Inpatient Care Group: The Management of Diabetic Ketoacidosis in Adults . Safe and Effective use of Insulin in Hospitalised Patients . Emotional and Psychological Support and Care in Diabetes Report from the emotional and psychological support working group of NHS Diabetes and Diabetes UK . Self monitoring of blood glucose in non-insulin-treated Type 2 diabetes . Diabetes - put your feet first. Top tips: foot care information for people with diabetes (So...<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
No association between thiazolidinedione exposure and DME
Exposure to thiazolidinediones is not associated with increased risk for diabetic macular edema in patients with Type 2 diabetes, suggest study results. (Source: MedWire News - Diabetes)
Thiazolidinediones Not Linked to Diabetic Macular Edema
In patients with type 2 diabetes, thiazolidinedione exposure is not associated with an increased risk of diabetic macular edema. In addition, an intravitreous dexamethasone drug delivery system shows promise in the treatment of persistent diabetic macular edema, according to research published in the March issue of the Archives of Ophthalmology. (Source: Modern Medicine)
In Vitro Potential of Ascophyllum nodosum Phenolic Antioxidant-Mediated α-Glucosidase and α-Amylase Inhibition
This study suggests a nutraceutical potential of A. nodosum based on phytochemical antioxidant and antihyperglycemia activities. (Source: Journal of Food Science)
Diamyd Medical: Diamyd US Phase III Study Well Under Way
Diamyd Medical (STO:DIAMB)(Pink Sheets:DMYDY) announces today that one hundred study participants have been included in the ongoing US Phase III study, DiaPrevent. The global Phase III program with the company's lead drug candidate Diamyd® has thereby enrolled more than 430 children newly diagnosed with type 1 diabetes in Europe and the USA. One hundred patients are now enrolled in the company's US Phase III study called DiaPrevent at 33 diabetes centers throughout the USA and more sites will be added... (Source: Health News from Medical News Today)
Diamyd Medical: Diamyd US Phase III Study Well Under Way
Diamyd Medical (STO:DIAMB)(Pink Sheets:DMYDY) announces today that one hundred study participants have been included in the ongoing US Phase III study, DiaPrevent. The global Phase III program with the company's lead drug candidate Diamyd® has thereby enrolled more than 430 children newly diagnosed with type 1 diabetes in Europe and the USA... (Source: Diabetes News From Medical News Today)<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Treatment of Gestational Diabetes Does Not Affect Childhood BMI
While treatment of gestational diabetes markedly reduces macrosomia at birth, it does not reduce the infant's risk of a high body mass index (BMI) in early childhood. Reuters Health Information (Source: Medscape Medical News Headlines)
Thiazolidinediones Don't Cause Macular Edema: Study
Thiazolidinediones don't seem to cause macular edema in type 2 diabetics, the ACCORD Study Group reports. Reuters Health Information (Source: Medscape Medical News Headlines)
Adherence Studies in Adolescents with Chronic Kidney or Urologic Diseases, or Diabetes (R01)
Request for Applications from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Nitric oxide reduces SLC29A1 promoter activity and adenosine transport involving transcription factor complex hCHOP-C/EBP{alpha} in human umbilical vein endothelial cells from gestational diabetes
Conclusion The hCHOP–C/EBP complex down-regulates SLC29A1 expression in an NO-dependent manner in HUVECs from gestational diabetes. (Source: Cardiovascular Research)
18F-fluorodeoxyglucose positron emission tomography immediately after chemoradiotherapy predicts prognosis in patients with locoregional postoperative recurrent esophageal cancer
Conclusions  FDG-PET performed even <7 days after chemoradiotherapy predicts prognosis in patients with postoperative recurrent esophageal cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-010-0044-yAuthors Keiichi Jingu, Tohoku University School of Medicine Department of Radiation Oncology 1-1 Seiryo-machi, Aoba-ku Sendai 980-8574 JapanTomohiro Kaneta, Tohoku University School of Medicine Department of Diagnostic Radiology Sendai JapanKenji Nemoto, Yamagata University School of Medicine Department of Radiation Oncology Yamagata JapanKen Takeda, Tohoku University School of Medicine Department of Radiation Oncology 1-1 Seiryo-machi, Aoba-ku Sendai 980-8574 JapanYoshihiro Ogawa, Tohoku University School of Medicine Department of Rad...<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Serum Cyfra 21.1 and galectin-3 protein levels in relation to immunohistochemical cytokeratin 19 and galectin-3 expression in patients with thyroid tumors
Conclusions  While CK19 and gal-3 are accurate as tissue markers, their serum levels could not be used as reliable markers for identification of thyroid malignancy or in thyroid cancer follow-up. On the other hand, a tendency toward higher serum levels of Cyfra 21.1 in the small number of PDTC patients examined adds weight to previous reports postulating a role for cytokeratins in predicting a high degree of malignancy. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0838-3Authors Tijana I?i?, University of Belgrade Institute for the Application of Nuclear Energy, INEP Banatska 31b 11080 Zemun, Belgrade SerbiaSvetlana Savin, University of Belgrade Institute for the Application of Nuclear Energy, INEP Banatska 31b 11080 Zemun, Belgrade Ser...
L-Arginine in pregnant scleroderma patients
Abstract  Systemic sclerosis (SSc) pregnant women show a high frequency of premature births and occurrence of renal crisis. Some evidences showed the role of L-arginine in the prevention and treatment of preeclampsia. Here, we report our experience on the effect of L-arginine treatment in four consecutive SSc pregnant women. Two patients, who have planned the pregnancy, were treated with oral L-arginine; both delivered healthy babies without any prenatal complications. The other two, with high risk of pregnancy complications because of severe lung involvement and type 1 diabetes, respectively, underwent i.v. L-arginine: patient 3 had a premature delivery of a 2-kg healthy baby, while patient 4 developed preeclampsia and, at the 28th week, delivered a 1,050-g girl. The neonate...
Late mortality in pediatric patients with craniopharyngioma
Abstract  Ten year survival rates for patients with craniopharyngioma vary from 24 to 100%. A review of the database of all children diagnosed with craniopharyngioma in British Columbia (BC) revealed that several patients died >10 years after diagnosis. This retrospective study investigates the causes and timing of deaths and reports the overall survival in this population based group of patients. A chart review was conducted on all patients aged <17 years, diagnosed in BC with craniopharyngioma between 1967 and 2003. Imaging studies were reviewed by a neuroradiologist. All deaths in the province are reported to a central agency, which allowed identification of patients who died after being lost to clinical follow up. Forty-one patients were identified with ...
Entering and Exiting the Medicare Part D Coverage Gap: Role of Comorbidities and Demographics
CONCLUSIONS  Certain chronically ill MAPD enrollees are at high risk of gap entry and exposure to unsubsidized medication costs. Clinically vulnerable populations should be counseled on how to best manage costs through drug substitution or discontinuation of specific, non-essential medications. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11606-010-1300-6Authors Susan L. Ettner, David Geffen School of Medicine at UCLA Division of General Internal Medicine and Health Services Research, Department of Medicine 911 Broxton Plaza Los Angeles CA 90024 USANeil Steers, David Geffen School of Medicine at UCLA Division of General Internal Medicine and Health Services Research, Department of Medicine 911 Broxton Plaza Los Angeles CA 90024 USAO. Kenrik Duru,...
Pioglitazone modulates tumor cell metabolism and proliferation in multicellular tumor spheroids
Abstract  The anti-diabetic thiazolidinedione compound pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, and selective cyclooxygenase-2 inhibitors are clinically used in patients with advanced malignancies. Several previously published in vivo and in vitro studies showed growth inhibitory effects on different cancer cell lines. However, the underlying mechanisms are fairly unclear. Here, we analyzed the effects of pioglitazone in combination with other drugs in a three-dimensional multicellular tumor spheroid culture system (MCTS) generated from the two prostate carcinoma cell lines PC3 and LNCaP. As expected, pioglitazone also inhibited tumor cell proliferation in the MCTS system. Further studies revealed that pioglitazone lowered the pH of the cult...<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Diabetes and cardiovascular disease
Abstract  Compelling evidence has been accumulating that hyperglycemia is independently related with excessive morbidity and mortality in cardiovascular disease (CVD) involving all components of the ?gluco-triade?, i.e., HbA1c, fasting plasma glucose, and postprandial or postload plasma glucose. Today's policy for blood glucose-lowering therapy must be ?reach and maintain glycemic goals safely and gently.? All available drug options provide a (placebo substracted) HbA1c decrease of around 1%. Due to the often much higher demand for lowering HbA1c, double combinations and even triple therapies are necessary. Avoiding side effects, especially hypoglycemia and too much weight gain, seems to be a priority of today's blood glucose-lowering therapy. The effectiveness of b...
The ApoB/ApoA1 Ratio is Associated with Metabolic Syndrome and its Components in a Chinese Population
In this study, we assessed whether the apolipoprotein B/apolipoprotein A1 ratio (ApoB/ApoA1) is related to metabolic syndrome (MS) and its components in an urban Chinese population. A total of 709 community residents were enrolled. Metabolic syndrome was defined according to the International Diabetes Federation definition in 2005. The high ApoB/ApoA1 group was defined as the gender-specific upper quartile of the ApoB/ApoA1 ratio. Insulin resistance (IR) was defined as the upper quartile of Homa-IR. The ApoB/ApoA1 ratio was significantly higher in subjects with MS, compared to those without (p?<?0.05). After adjusting for age and gender, subjects with MS (odds ratio [OR]?=?3.5) or IR (OR?=?2.3) were more likely to be in the high ApoB/ApoA1 group. The ApoB/ApoA1 ratio in...
Type 2 diabetes impairs pulmonary function in morbidly obese women: a case?control study
Conclusions/interpretation  The presence of diabetes and the degree of glycaemic control are related to respiratory function impairment in morbidly obese women. Therefore, the impact of type 2 diabetes on pulmonary function should be taken into consideration by those providing care for obese people. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1700-5Authors A. Lecube, Institut de Recerca Hospital Universitari Vall d?Hebron CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Diabetes and Metabolism Research Unit Passeig Vall d?Hebron, 119-129 08035 Barcelona SpainG. Sampol, Institut de Recerca Hospital Universitari Vall d?Hebron CIBER Enfermedades Respiratorias (CIBERES), Instituto de ...
Overexpression of the orphan receptor Nur77 alters glucose metabolism in rat muscle cells and rat muscle in vivo
Conclusions/interpretation  Our data provide compelling evidence that NUR77 is a functional regulator of glucose metabolism in skeletal muscle in vivo. Importantly, the diminished content in muscle of obese insulin-resistant men suggests that it might be a potential therapeutic target for the treatment of dysregulated glucose metabolism. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1703-2Authors T. Kanzleiter, Garvan Institute of Medical Research Diabetes and Obesity Research Program 384 Victoria Street, Darlinghurst Sydney NSW 2010 AustraliaE. Preston, Garvan Institute of Medical Research Diabetes and Obesity Research Program 384 Victoria Street, Darlinghurst Sydney NSW 2010 AustraliaD. Wilks, Garvan Institute of Medical Research Diabetes and O...
Determinants of glucose control in patients with chronic pancreatitis
Conclusions/interpretation  Hyperglycaemia in CP patients is associated with reduced beta cell area. However, reduced beta cell area does not predict the development of diabetes, suggesting that other factors are more important determinants of alterations in glucose metabolism in patients with CP. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1705-0Authors H. Schrader, Ruhr-University Bochum Department of Medicine I, St Josef-Hospital Gudrunstr. 56 44791 Bochum GermanyB. A. Menge, Ruhr-University Bochum Department of Medicine I, St Josef-Hospital Gudrunstr. 56 44791 Bochum GermanyC. Zeidler, Ruhr-University Bochum Department of Medicine I, St Josef-Hospital Gudrunstr. 56 44791 Bochum GermanyP. R. Ritter, Ruhr-University Bochum Department of Medic...<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Diabetic ketoacidosis at diagnosis in Austrian children in 1989?2008: a population-based analysis
Conclusions  The overall frequency of DKA in children with newly diagnosed type 1 diabetes in Austria is high and has not changed during the last 20 years despite a clear increase in the manifestation rate. In particular, children less than 2 years of age have a high risk of DKA at onset. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1704-1Authors E. Schober, Medical University of Vienna Department of Pediatrics Währinger Gürtel 18?20 1090 Vienna AustriaB. Rami, Medical University of Vienna Department of Pediatrics Währinger Gürtel 18?20 1090 Vienna AustriaT. Waldhoer, Medical University of Vienna Department of Epidemiology, Center of Public Health Vienna Austriaon behalf of the Austrian Diabetes Incidence Study Group Jou...
Impact of metabolic indices on central artery stiffness: independent association of insulin resistance and glucose with aortic pulse wave velocity
Conclusions/interpretation  IGR characterised by fasting or post-challenge hyperglycaemia is associated with significant vascular stiffening. Post-challenge glucose and HOMA-IR are the most powerful metabolic predictors of arterial stiffness, implying hyperglycaemic excursion and insulin resistance play important roles in the pathogenesis of arteriosclerosis. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1689-9Authors D. R. Webb, University of Leicester Diabetes and Vascular Research Group, Department of Cardiovascular Sciences Leicester LE1 5WW UKK. Khunti, University of Leicester Department of Health Sciences Leicester UKR. Silverman, University of Leicester Diabetes and Vascular Research Group, Department of Cardiovascular Sciences Leicester L...
High normal fasting glucose level in obese youth: a marker for insulin resistance and beta cell dysregulation
Conclusions/interpretation  These data suggest that in obese youth, independent of age, BMI z score, sex, family history and ethnicity, insulin sensitivity and secretion decline when moving from low to high normal fasting plasma glucose. The simple measure of fasting plasma glucose could assist clinicians in identifying children for targeted diabetes screening and subsequent lifestyle management. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1693-0Authors G. O?Malley, Yale University School of Medicine Department of Pediatrics 330 Cedar Street PO Box 208064 New Haven CT 06520 USAN. Santoro, Yale University School of Medicine Department of Pediatrics 330 Cedar Street PO Box 208064 New Haven CT 06520 USAV. Northrup, Yale Center for Clinical Inv...
Gender-related differences in outcome after ST-segment elevation myocardial infarction treated by primary angioplasty and glycoprotein IIb?IIIa inhibitors: insights from the EGYPT cooperation
This study shows that in patients with STEMI treated by primary angioplasty, female gender is associated with higher mortality rate in comparison with men, and this is mainly due to their higher clinical and angiographic risk profiles. In fact, female sex did not emerge as an independent predictor of mortality. Content Type Journal ArticleDOI 10.1007/s11239-010-0451-yAuthors Giuseppe De Luca, Eastern Piedmont University Division of Cardiology, Maggiore della Carità Hospital Novara ItalyC. Michael Gibson, Harvard Medical School Beth Israel Deaconess Medical Center Boston USAMariann Gyöngyösi, Medical University of Vienna Department of Cardiology Vienna AustriaUwe Zeymer, Herzzentrum Ludwigshafen Division of Cardiology Ludwigshafen GermanyDariusz Dudek, Jagiellonian University II...
The Association Between Gestational Diabetes Mellitus and Recreational Physical Activity
Abstract  We aimed to investigate the association of recreational physical activity before pregnancy with gestational diabetes mellitus (GDM). A cross-sectional study was performed using self-reported data from the Pregnancy Risk Assessment and Monitoring System. The study population included 1,052 self-reported GDM cases and 10,351 non-GDM controls. Recreational physical activity in the 3 months before pregnancy was recalled in postpartum structured interviews. Compared to women exercising less than 1 day per week, women who exercised >5 days per week in the 3 months before pregnancy had a 31% lower odds of GDM (adjusted odds ratio [aOR]: 0.69; 95% confidence interval [CI]: 0.46, 1.03). Women who exercised 1?4 days per week had a 7% lower odds ...<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Japanese consensus guidelines for management of autoimmune pancreatitis: III. Treatment and prognosis of AIP
Abstract  Steroid therapy appeared to be a standard treatment for autoimmune pancreatitis (AIP), although some AIP patients improve spontaneously. The indications for steroid therapy in AIP patients are symptoms such as obstructive jaundice, abdominal pain, and back pain, and the presence of symptomatic extrapancreatic lesions. Before steroid therapy, jaundice should be managed by biliary drainage in patients with obstructive jaundice, and blood glucose levels should be controlled in patients with diabetes mellitus. For the initial oral prednisolone dose for induction of remission, 0.6 mg/kg/day is recommended. The initial dose is administered for 2?4 weeks, and the dose is tapered by 5 mg every 1?2 weeks, based on changes in the clinical manifestatio...
Diabetics on hemodialysis in El-Minia Governorate, Upper Egypt: five-year study
Conclusion  Diabetic nephropathy among HD patients in El-Minia Governorate is increasing but is less prevalent than in the United States and other Western countries, probably because of a higher incidence of other causes of ESRD in El-Minia governorate, or because of premature death of diabetic patients. Therefore, meticulous management of diabetic patients is mandatory. Content Type Journal ArticleCategory Nephrology ? Original PaperDOI 10.1007/s11255-010-9713-zAuthors Osama El-Minshawy, El Minia University School of Medicine Department of Internal Medicine El Minia EgyptEmad G. Kamel, El Minia University School of Medicine Department of Public Health El Minia Egypt Journal International Urology and NephrologyOnline ISSN 1573-2584Print ISSN 0301-1623 (Sourc...
Minocycline with aspirin: a therapeutic approach in the treatment of diabetic neuropathy
Abstract  Enhanced production of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in diabetes leads to degradation of extracellular matrix in blood vessels and leads to complications of diabetes. In the present study, we have targeted MMP-2 and MMP-9 overactivation in diabetic neuropathy using a known MMP-2 and MMP-9 inhibitor, minocycline, with a non-selective COX inhibitor, aspirin. Streptozotocin-induced diabetic neuropathy was carried out in male Wistar rats and monitored by measuring the sensory nerve conduction velocity (SNCV), motor nerve conduction velocity (MNCV), tail flick latency and hot plate latency. Three weeks of treatment with a combination of minocycline and aspirin showed significant improvement in SNCV, MNCV, hot plate latency an...
Influence of Lys656asn Polymorphism of Leptin Receptor Gene on Surgical Results of Biliopancreatic Diversion
Conclusion  Weight loss was higher in mutant group (Lys656Asn and Asn656Asn) than wild-type group (Lys656Lys) after bariatric surgery. Carriers of the allelic variant (Asn) had higher basal weight. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11605-010-1181-3Authors Daniel Antonio de Luis, University of Valladolid Institute of Endocrinology and Nutrition, Medicine School. Unit of Investigation and Endocrinology Department, Hospital Rio Hortega Valladolid 47130 SpainRocio Aller, University of Valladolid Institute of Endocrinology and Nutrition, Medicine School. Unit of Investigation and Endocrinology Department, Hospital Rio Hortega Valladolid 47130 SpainManuel González Sagrado, University of Valladolid Institute of Endocrinology and Nutrition, Me...
Insulin glargine effective for treating nonobese and obese Type 2 diabetics
Results from a subgroup analysis of the ATLANTUS trial show that treatment with insulin glargine is effective for lowering glycated hemoglobin, without substantial weight gain, in obese and nonobese individuals with Type 2 diabetes. (Source: MedWire News - Diabetes)<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Editorial Board
(Source: Diabetes Research and Clinical Practice)
Sitagliptin: A Review of its Use in the Management of Type 2 Diabetes Mellitus
(Source: Drugs)
Circulating osteocalcin concentrations are associated with parameters of liver fat infiltration and increase in parallel to decreased liver enzymes after weight loss
Conclusions  In summary, our findings suggest a bone?liver axis in which osteocalcin might be the active regulator. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-010-1174-9Authors J. M. Fernández-Real, Institut d?Investigació Biomédica de Girona (IdIBGi) CIBEROBN Fisiopatología de la Obesidad y Nutrición CB06/03/010 Department of Diabetes, Endocrinology and Nutrition Girona Catalonia SpainF. Ortega, Institut d?Investigació Biomédica de Girona (IdIBGi) CIBEROBN Fisiopatología de la Obesidad y Nutrición CB06/03/010 Department of Diabetes, Endocrinology and Nutrition Girona Catalonia SpainJ. Gómez-Ambrosi, University of Navarra Department of Endocrinology Pamplona SpainJ. Salvador, University of Navarra Department of Endocrinology P...
The hormonal profile of hip fracture female patients differs from community-dwelling peers over a 1-year follow-up period
Conclusions  Older women who have sustained a hip fracture have progressive changes in hormonal milieu that exceed those of women of similar health status during the year following fracture. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00198-010-1187-4Authors A. R. Cappola, University of Pennsylvania School of Medicine Division of Endocrinology, Diabetes and Metabolism 764 CRB, 415 Curie Blvd. Philadelphia PA 19104 USAW. G. Hawkes, University of Maryland Division of Gerontology, Department of Epidemiology and Preventive Medicine Baltimore MD USAN. Blocher, Albert Einstein Medical Center Division of Endocrinology Philadelphia PA USAJ. Yu-Yahiro, The Union Memorial Hospital Department of Orthopaedic Surgery Baltimore MD USAD. Orwig, University of...
Effects of antioxidants on postprandial oxidative stress and endothelial dysfunction in subjects with impaired glucose tolerance and Type 2 diabetes
Conclusions  In diabetic subjects, altered glycaemia and lipaemia are closely correlated with markers of systemic oxidative stress. Our results show that the abnormal changes in oxidative-reductive balance parameters are paralleled by similar changes in markers of endothelial dysfunction and inflammation at 4 h after ingestion of a fatty meal. Supplementation with a pool of antioxidants can reduce oxidative stress and inflammation in healthy subjects and, more importantly, in IGT patients. This previous aspect suggests that the timing of antioxidant supplementation has an important role in endothelium protection in healthy and pre-diabetic subjects, and along with prompt antioxidant treatment before irreversible endothelial damage has occurred, may have an important pr...<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Hemoglobin A1c outperforms fasting glucose for risk prediction
Measurements of hemoglobin A1c (HbA1c) more accurately identify persons at risk for clinical outcomes than the commonly used measurement of fasting glucose, according to a new study. HbA1c levels accurately predict future diabetes, and they better predict stroke, heart disease and all-cause mortality as well. (Source: ScienceDaily Headlines)
Prevalence of dementia disorders in the oldest-old: an autopsy study
Abstract  The prevalence of Alzheimer disease (AD) and vascular dementia (VD) increases with advancing age, but less so after age 90 years. A retrospective hospital-based study of the relative prevalence of different disorders was performed in 1,110 consecutive autopsy cases of demented elderly in Vienna, Austria (66% females, MMSE <20; mean age 83.3 ± 5.4 SD years). It assessed clinical, general autopsy data and neuropathology including immunohistochemistry. Neuropathologic diagnosis followed current consensus criteria. Four age groups (7?10th decade) were evaluated. In the total cohort AD pathology was seen in 82.9% (?pure? AD 42.9%; AD + other pathologies 39.9%), VD in 10.8% (mixed dementia, MIX, i.e. AD + vascular encepha...
Missing published and unpublished data in guidelines
(Source: BMJ Online First)
Features at Diagnosis of 324 Patients With Acromegaly Did Not Change Fom 1981 to 2006: Acromegaly Remains Under-recognized and Under-diagnosed
Traditionally, acromegaly evaded diagnosis until in its clinically obvious later stages when treatment is more difficult. Clinical Endocrinology (Source: Medscape Today Headlines)
One's Enough: People Who Donate a Kidney Live Just as Long as Those Who Don't
Every 30 minutes, all of the blood in our bodies is filtered through two fist-size kidneys. But diseases such as diabetes can cause them to fail, leading to a build-up of chemicals in the blood that without dialysis (mechanical blood filtration) or a kidney transplant would be fatal. And the wait for a new kidney can be long, unless someone you know is willing to give one of theirs to you. [More] (Source: Scientific American Topic - Medical Technology)<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Endocrinology & Diabetes Research Associate - University of Manchester
Added via the University of Manchester jobs page. The Endocrinology and Diabetes group at the University of Manchester have an exciting opening for a postdoctoral Research Associate for up to 5 years, funded by a Wellcome Trust fellowship programme awarded to Professor Neil Hanley. The successful applicant will study the mechanisms by which pancreatic beta-cells arise during development, with the aim of providing new insights into beta-cell regeneration. Evidence of a productive research background, ideally relating to the pancreas, is required. The deadline for applications is 18 March 2010. Please visit the University of Manchester jobs page (below) for more information. Further details (Source: Society for Endocrinology)
One's Enough: People Who Donate a Kidney Live Just as Long as Those Who Don't
Every 30 minutes, all of the blood in our bodies is filtered through two fist-size kidneys. But diseases such as diabetes can cause them to fail, leading to a build-up of chemicals in the blood that without dialysis (mechanical blood filtration) or a kidney transplant would be fatal. And the wait for a new kidney can be long, unless someone you know is willing to give one of theirs to you. [More] (Source: Scientific American - Official RSS Feed)
Hepatitis C And Insulin Resistance - Surprising Findings
We have known for several years that Hepatitis C, a common cause of liver cirrhosis and cancer, also makes people three to four times more likely to develop Type 2 diabetes. In studying the insulin resistance of 29 people with Hepatitis C, Australian researchers have confirmed that they have high insulin resistance, a precursor to diabetes. However, almost all insulin resistance occurs in muscle, with little or none in the liver, a very surprising finding given that Hepatitis C is a liver disease... (Source: Health News from Medical News Today)
Hepatitis C And Insulin Resistance - Surprising Findings
We have known for several years that Hepatitis C, a common cause of liver cirrhosis and cancer, also makes people three to four times more likely to develop Type 2 diabetes. In studying the insulin resistance of 29 people with Hepatitis C, Australian researchers have confirmed that they have high insulin resistance, a precursor to diabetes... (Source: Diabetes News From Medical News Today)
Diamyd Medical: Diamyd US Phase III Study Well under Way
STOCKHOLM--(HSMN NewsFeed)--Diamyd Medical (STO:DIAMB)(Pink Sheets:DMYDY ) announces today that one hundred study participants have been included in the ongoing US Phase III study, DiaPrevent. The global Phase III program with the company’s lead drug candi... Biopharmaceuticals, EndocrinologyDiamyd Medical, DiaPrevent, Diamyd, diabetes (Source: HSMN NewsFeed)<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Professor Discovers Link Between Low Oxygen Levels In Body And Cancer-Aiding Protein; Could Help Treatments For Retinoblastoma, Breast Cancer
What began as research into how diabetics could possibly preserve their eyesight has led to findings that could prolong the vision of children afflicted with retinoblastoma. Dolores Takemoto, a Kansas State University professor of biochemistry who was researching protein kinase C gamma in the lens of the human eye, found her work taking a fascinating turn when she discovered a correlation between the protein Coonexin46 and hypoxia -- a deficiency of oxygen which kills normal tissue cells. According to the data, Coonexin46, or Cx46, appears in the body during these levels of low oxygen... (Source: Health News from Medical News Today)
Starting Treatment Early Doubles Chance Of Success For People With Diabetes
The sooner people with diabetes start taking metformin, the longer the drug remains effective, according to a Kaiser Permanente study published in the March issue of Diabetes Care, a journal of the American Diabetes Association. The study found that metformin, an inexpensive, generic drug that helps patients prevent dangerously high blood sugar levels, worked nearly twice as long for people who began taking it within three months of their diabetes diagnosis. This is the first study to compare metformin failure rates in a real-world, clinical practice setting... (Source: Health News from Medical News Today)
Professor Discovers Link Between Low Oxygen Levels In Body And Cancer-Aiding Protein; Could Help Treatments For Retinoblastoma, Breast Cancer
What began as research into how diabetics could possibly preserve their eyesight has led to findings that could prolong the vision of children afflicted with retinoblastoma... (Source: Breast Cancer News From Medical News Today)
Starting Treatment Early Doubles Chance Of Success For People With Diabetes
The sooner people with diabetes start taking metformin, the longer the drug remains effective, according to a Kaiser Permanente study published in the March issue of Diabetes Care, a journal of the American Diabetes Association... (Source: Diabetes News From Medical News Today)
Dr. Gabriel Cousens reveals method for reversing diabetes with raw living foods in exclusive interview
(NaturalNews) This is a "must listen" interview for anyone suffering from diabetes, obesity or blood sugar disorders. It's commercial-free and it's a free download of an MP3 file that will play on any computer or MP3 player. What you'll hear in this interview will absolutely astound you -- it rocks the world of conventional medicine and its failed diabetes treatments.This is an interview with Dr. Gabriel Cousens, founder of the Tree of Life Rejuvenation Center in Patagonia, Arizona (www.TreeofLife.nu). In this audio interview, you'll hear Dr. Cousens describe why and how consuming raw foods really works to initiate dramatic reductions in fasting blood sugar levels, effectively reversing diabetes in a matter of just a few weeks.This is essentially a cure for diabetes. Not coincidentally, Dr...<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Over 130,000 cases of diabetes now linked to soda consumption, HFCS
(NaturalNews) For years, advocates of natural health have been hammering away at the message that soda causes diabetes and obesity. The soda industry, meanwhile, has remained in denial mode, mirroring the ridiculous position of the tobacco industry that "nicotine is not addictive." Soda doesn't cause diabetes, the industry claims, and it's perfectly safe to consume in essentially unlimited quantities.The Corn Refiners Association has joined the denial with its own spin campaign that seeks to convince people High-Fructose Corn Syrup (HFCS) is totally natural and completely harmless. HFCS is, of course, the primary sweetener used in sodas and soft drinks.Now comes new research presented at the American Heart Association's Cardiovascular Disease Epidemiology and Prevention annual conference i...
Health Tip: Are You at Greater Risk of Pneumonia?
Title: Health Tip: Are You at Greater Risk of Pneumonia?Category: Health NewsCreated: 3/9/2010 10:10:00 AMLast Editorial Review: 3/10/2010 (Source: MedicineNet Diabetes General)
Cost of Junk Food May Influence Consumption
Title: Cost of Junk Food May Influence ConsumptionCategory: Health NewsCreated: 3/9/2010 10:10:00 AMLast Editorial Review: 3/10/2010 (Source: MedicineNet Diabetes General)
Alzheimer's 'Epidemic' Hitting Minorities Hardest
Title: Alzheimer's 'Epidemic' Hitting Minorities HardestCategory: Health NewsCreated: 3/9/2010 10:10:00 AMLast Editorial Review: 3/10/2010 (Source: MedicineNet Diabetes General)
Obese Colon Cancer Survivors Face Poorer Prognosis
Title: Obese Colon Cancer Survivors Face Poorer PrognosisCategory: Health NewsCreated: 3/9/2010 2:10:00 PMLast Editorial Review: 3/10/2010 (Source: MedicineNet Diabetes General)<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Most Drug Studies Don't Help Docs Pick Best Treatment
Title: Most Drug Studies Don't Help Docs Pick Best TreatmentCategory: Health NewsCreated: 3/9/2010 4:10:00 PMLast Editorial Review: 3/10/2010 (Source: MedicineNet Diabetes General)
Nitric oxide-releasing wrap for donor organs and cloth for therapeutic socks
(American Chemical Society) Scientists in Texas are reporting development of a first-of-its-kind cloth that releases nitric oxide gas -- an advance toward making therapeutic socks for people with diabetes and a wrap to help preserve organs harvested for transplantation. The study is in ACS' Chemistry of Materials, a bi-weekly journal. (Source: EurekAlert! - Medicine and Health)
Sodium-Glucose Co-Transport Inhibitors: Progress and Therapeutic Potential in Type 2 Diabetes Mellitus
(Source: Drugs)
Diabetes drug effective if taken early
PORTLAND, Ore., March 9 (UPI) -- The sooner people with diabetes take the generic drug Metformin that helps prevent high blood sugar levels, the longer it is effective, U.S. researchers said. (Source: Health News - UPI.com)
Scotland backs saxagliptin for type-2 diabetes
People in Scotland with type-2 diabetes now have access to a wider choice of treatments after saxagliptin (Onglyza) was accepted for use within NHS Scotland. (Source: HealthcareRepublic Press Releases)<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Resting Heart Rate and Metabolic Syndrome in Patients With Diabetes and Coronary Artery Disease in Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial
Prev Cardiol. ****;**:**[ndash]**. The relation between the metabolic syndrome (MetS) and resting heart rate (rHR) in patients with diabetes and coronary artery disease is unknown. The authors examined the cross-sectional association at baseline between components of the MetS and rHR and between rHR and left ventricular ejection fraction in the population from the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) randomized clinical trial. The mean rHR in the MetS group was significantly higher than in those without (68.4±12.3 vs 65.6±11.8 beats per min, P=.0017). The rHR was higher (P (Source: Preventive Cardiology)
Drug utilization of oral hypoglycemic agents in a university teaching hospital in India
Conclusion: This study strongly highlights the need for patient education or counselling on use of antidiabetic and concomitant drugs, monitoring of blood glucose and glycosylated haemoglobin (HbA1c) levels, diet control, and correction of diabetic complications. Metabolic control was poor and HbA1c monitoring was underutilized. Clinical monitoring of patients' adherence to prescribed treatments is recommended and measures should be taken to improve it. (Source: Journal of Clinical Pharmacy and Therapeutics)
JinQi-Jiangtang tablet, a Chinese patent medicine, for pre-diabetes: a randomized controlled trial
DiscussionThe aim of this study is to evaluate the effectiveness and safety of JinQi JiangTang (JQJT) tablets for the treatment of patients with pre-diabetes.Trial registrationChinese clinical trials register ChiCTR-TRC-00000401 (Source: Trials)
Non-Langerhans cell histiocytosis with isolated CNS involvement: An unusual variant of Erdheim-Chester disease
We report a 58-year-old Caucasian woman who presented with diabetes insipidus and was found to harbor a large suprasellar mass. Histopathological analysis was consistent with non-LCH. The differential diagnoses included juvenile xanthogranuloma, adult-onset xanthogranuloma, xanthoma disseminatum, Rosai-Dorfman disease, and Erdheim-Chester disease. Immunohistochemical examination demonstrated a proliferation of large lipid-laden histiocytic cells which were positive for CD68, negative for S100 protein, and showed only faint, background staining for CD1a. We present a case of an autopsy-confirmed non-Langerhans cell histiocytosis limited to the central nervous system and evaluated with both immunohistochemical and ultrastructural studies. Based on the multifocality, anatomic distribution, an...
A high-protein low-fat diet is more effective in improving blood pressure and triglycerides in calorie-restricted obese individuals with newly diagnosed type 2 diabetes
Authors: E Papakonstantinou, D Triantafillidou, D B Panagiotakos, A Koutsovasilis, M Saliaris, A Manolis, A Melidonis & A Zampelas (Source: European Journal of Clinical Nutrition)<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus
Bristol-Myers Squibb Company (NYSE: BMY) and AstraZeneca (NYSE: AZN) announced the commencement of the "Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus" trial (SAVOR-TIMI 53), a multicenter, randomized, double-blind, placebo-controlled Phase 4 study, to evaluate treatment with ONGLYZA? (saxagliptin), a dipeptidyl peptidase-4 (DPP4) inhibitor, in adult type 2 diabetes patients with cardiovascular risk factors. (Source: World Pharma News)
iViva Bien!: Overcoming Recruitment Challenges in a Multiple-Risk-Factor Diabetes Trial
Conclusions: Using appropriate recruitment procedures, a representative sample of Latinas can be obtained. (Source: American Journal of Health Behavior)
March is "Save Your Vision" Month
Did you know that diabetic retinopathy is a leading cause of blindness in the U.S. today? According to the National Diabetes Information Clearinghouse, between 12,000 to 24,000 new cases of blindness every year are attributed to diabetes. If you have diabetes, what can you do to protect your vision? Try to keep your blood sugar levels in a normal range. High blood sugar can damage delicate blood vessels in the eye. Visit an eye doctor regularly for checkups. If you notice any changes in your vision, call your eye doctor immediately. More from your diabetes guide... What to Know About Diabetic Retinopathy Photo courtesy of Medioimages/Photodisc/Getty Images March is "Save Your Vision" Month originally appeared on About.com Diabetes on Wednesday, March 10th, 2010 at 01:03:01.Permalink | ...
WBC linked to metabolic syndrome risk, severe psychiatric symptoms in schizophrenia
White blood cell count may be useful for predicting the metabolic syndrome and more severe psychiatric symptoms in non-diabetic patients with schizophrenia, say US researchers. (Source: MedWire News - Psychiatry)
Protect Your Kidneys, Control Diabetes, Op-ed
NOTE: The following is an op-ed piece by Susan MacNeil, manager, Nova Scotia Renal Program. Diabetes is the leading cause of kidney disease. More than 40 per cent of people that need dialysis also have diabetes. (Source: Government of Nova Scotia News Releases - Health)<div id="medworm">MedWorm Message: Get the very latest Swine Flu news via the MedWorm <a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a> - updated hourly from thousands of authoritative health and news sources.</div>
Beneficial Effects of L- and N-type Calcium Channel Blocker on Glucose and Lipid Metabolism and Renal Function in Patients with Hypertension and Type II Diabetes Mellitus
This study was undertaken to compare the efficacy of amlodipine (an inhibitor of L-type calcium channels) and cilnidipine (an inhibitor of both L-type and N-type calcium channels) in patients with hypertension and type II diabetes mellitus. Seventy-seven hypertensive patients were divided into two groups according to presence/absence of type II diabetes mellitus. In these two groups of patients, the effects of amlodipine and cilnidipine on glucose and lipid metabolism and renal function were compared. As for glucose and lipid metabolism, homeostasis model assessment insulin resistance (HOMA-R) level in the non-diabetic group and triglyceride in the diabetes group were significantly lower with cilnidipine than with amlodipine. As regards renal function in the diabetic group, estimated glome...
Paradoxical Decrease in High-Density Lipoprotein Cholesterol with Fenofibrate: A Quite Rare Phenomenon Indeed
Some recent clinical reports have suggested that paradoxical decreases in high-density lipoprotein cholesterol (HDL-C) levels after fenofibrate treatment may be quite common. These appear to occur mainly in patients with combined fibrate/statin therapy and possibly in those with low baseline HDL-C. Reports on HDL-C reductions after fenofibrate are possibly supported by the disappointing results in terms of HDL-C responses from the recent FIELD study. A survey on 581 patients treated for 1 year or longer was carried out in our Clinical Center. This indicated that paradoxical HDL-C reductions are a relatively uncommon phenomenon. Not more than 15.3% of the present series showed an HDL-C reduction, mostly of a modest degree. Further, reductions of HDL-C appear to occur mainly in individuals w...
Targeting the pentose phosphate pathway in syndrome X-related cardiovascular complications
Syndrome X is a combination or co-occurrence of several known cardiovascular risk factors (including central obesity, dyslipidemias, fatty liver disease, hyperinsulinemia, insulin resistance, and hypertension) that affects at least one in five people in developed countries. Syndrome X shortens life and increases morbidity by contributing to the development of both diabetes and cardiovascular disease. Type 1 or 2 diabetes affects approximately 170 million people globally, and these numbers are rapidly rising. In patients with diabetes, vascular diseases develop early and progress at an accelerated rate. It has recently become evident that glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose-phosphate pathway and its reaction products play key roles in regulating...
Evaluation of risk of overall mortality in patients with type 2 diabetes receiving glipizide, glyburide, or glimepiride monotherapy
Source: Diabetes Care Area: News According to research published early online in Diabetes Care, glimepiride may be the preferred sulfonylurea in those with underlying coronary artery disease (CAD).   Researchers evaluated the relationship of individual sulfonylureas and the risk of overall mortality in a cohort of patients with type 2 diabetes. The retrospective cohort study was conducted using an academic health centre enterprise-wide electronic health record (EHR) system to identify 11,141 patients with type 2 diabetes (4,279 initiators of monotherapy with glyburide, 4,325 initiators of monotherapy with glipizide, and 2,537 initiators of monotherapy with glimepiride), aged >18 years, with and without a history of CAD, and not on insulin or a non-insulin injectable at baselin...

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The Power Of The Pineapple, Plays A Major Role In The Body's Healing Process.
By James frey
For a natural and tasty way to improve your health and boost your healing capacity, add fresh pineapple and pineapple juice to your diet. Pineapples are nutritionally packed Read more...